Donaldson, G. C., Hurst, J. R., Smith, C. J., Hubbard, R. B. & Wedzicha, J. A. Increased risk of myocardial infarction and stroke following exacerbation of COPD. Chest 137(5), 1091–1097 (2010).
Sabit, R. et al. Arterial stiffness and osteoporosis in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175(12), 1259–1265 (2007).
McAllister, D. A. et al. Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 176(12), 1208–1214 (2007).
Maclay, J. et al. Vascular dysfunction in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. doi.org/10.1164/rccm.200903-0414OC (2009).
Mills, N. L. et al. Increased arterial stiffness in patients with chronic obstructive pulmonary disease: A mechanism for increased cardiovascular risk. Thorax 63(4), 306–311 (2008).
Yeboah, J., Crouse, J. R., Hsu, F. C., Burke, G. L. & Herrington, D. M. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The Cardiovascular Health Study. Circulation 115(18), 2390–2397 (2007).
Yeboah, J. et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 120(6), 502–509 (2009).
Patel, A. R. et al. Cardiovascular risk, myocardial injury, and exacerbations of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 188(9), 1091–1099 (2013).
Dweik, R. A. et al. An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am. J. Respir. Crit. Care Med. 184(5), 602–615 (2011).
Eickhoff, P. et al. Determinants of systemic vascular function in patients with stable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 178(12), 1211–1218 (2008).
Hingorani, A. D. et al. Acute systemic inflammation impairs endothelium-dependent dilatation in humans. Circulation 102(9), 994–999 (2000).
Marchetti, N. et al. Hospitalized acute exacerbation of COPD impairs flow and nitroglycerin-mediated peripheral vascular dilation. COPD 8(2), 60–65 (2011).
McNicholas, W. T., Verbraecken, J. & Marin, J. M. Sleep disorders in COPD: The forgotten dimension. Eur. Respir. Rev. 22(129), 365–375 (2013).
Vermeeren, M. A., Schols, A. M. & Wouters, E. F. Effects of an acute exacerbation on nutritional and metabolic profile of patients with COPD. Eur. Respir. J. 10(10), 2264–2269 (1997).
Albarrati, A. M., Gale, N. S., Munnery, M. M., Cockcroft, J. R. & Shale, D. J. Daily physical activity and related risk factors in COPD. BMC Pulm. Med. 20(1), 60 (2020).
Moy, M. L., Danilack, V. A., Weston, N. A. & Garshick, E. Daily step counts in a US cohort with COPD. Respir. Med. 106(7), 962–969 (2012).
Troosters, T. et al. Physical inactivity in patients with COPD, a controlled multi-center pilot-study. Respir. Med. 104(7), 1005–1011 (2010).
Waschki, B. et al. Physical activity monitoring in COPD: Compliance and associations with clinical characteristics in a multicenter study. Respir. Med. 106(4), 522–530 (2012).
Garcia-Aymerich, J., Lange, P., Benet, M., Schnohr, P. & Anto, J. M. Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: A population based cohort study. Thorax 61(9), 772–778 (2006).
Taylor, H. L. et al. Effects of bed rest on cardiovascular function and work performance. J. Appl. Physiol. 2(5), 223–239 (1949).
Convertino, V. A. Cardiovascular consequences of bed rest: Effect on maximal oxygen uptake. Med. Sci. Sports Exerc. 29(2), 191–196 (1997).
Arinell, K., Christensen, K., Blanc, S., Larsson, A. & Frobert, O. Effect of prolonged standardized bed rest on cystatin C and other markers of cardiovascular risk. BMC Physiol. 11, 17 (2011).
Jurdana, M. et al. Impact of 14-day bed rest on serum adipokines and low-grade inflammation in younger and older adults. Age (Dordr.) 37(6), 116 (2015).
Barnes, J. N. et al. Arterial stiffening, wave reflection, and inflammation in habitually exercising systemic lupus erythematosus patients. Am. J. Hypertens. doi.org/10.1038/ajh.2011.143 (2011).
Provan, S. A. et al. Early prediction of increased arterial stiffness in patients with chronic inflammation: A 15-year followup study of 108 patients with rheumatoid arthritis. J. Rheumatol. 38(4), 606–612 (2011).
Yiu, K. H. et al. Increased arterial stiffness in patients with psoriasis is associated with active systemic inflammation. Br. J. Dermatol. 164(3), 514–520 (2011).
van Bussel, B. C. et al. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension 58(4), 588–595 (2011).
Yasmin, McEniery CM. et al. Matrix metalloproteinase-9 (MMP-9), MMP-2, and serum elastase activity are associated with systolic hypertension and arterial stiffness. Arterioscler. Thromb. Vasc. Biol. 25(2), 372 (2005).
Yasmin, McEniery CM., Wallace, S., Mackenzie, I. S., Cockcroft, J. R. & Wilkinson, I. B. C-reactive protein is associated with arterial stiffness in apparently healthy individuals. Arterioscler. Thromb. Vasc. Biol. 24(5), 969–74 (2004).
O’Donnell, D. E., Sanii, R., Anthonisen, N. R. & Younes, M. Effect of dynamic airway compression on breathing pattern and respiratory sensation in severe chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 135(4), 912–918 (1987).
Laurent, S. et al. Expert consensus document on arterial stiffness: Methodological issues and clinical applications. Eur. Heart J. 27(21), 2588–2605 (2006).
Faizi, A. K., Kornmo, D. W. & Agewall, S. Evaluation of endothelial function using finger plethysmography. Clin. Physiol. Funct. Imaging 29(5), 372–375 (2009).
Bonetti, P. O. et al. Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia. J. Am. Coll. Cardiol. 44(11), 2137–2141 (2004).
Meeme, A., Buga, G. A., Mammen, M. & Namugowa, A. Endothelial dysfunction and arterial stiffness in pre-eclampsia demonstrated by the EndoPAT method. Cardiovasc. J. Afr. 28(1), 23–29 (2017).
Syvanen, K., Korhonen, P., Partanen, A. & Aarnio, P. Endothelial function in a cardiovascular risk population with borderline ankle-brachial index. Vasc. Health Risk Manag. 7, 97–101 (2011).
Subrahmanyam, R. M. et al. Can bronchial asthma be classified based on the immunological status?. Lung India 28(2), 110–113 (2011).
Takemura, M. et al. High sensitivity C-reactive protein in asthma. Eur. Respir. J. 27(5), 908–912 (2006).
Storm, F. A., Heller, B. W. & Mazza, C. Step detection and activity recognition accuracy of seven physical activity monitors. PLoS ONE 10(3), e0118723 (2015).
Vooijs, M. et al. Validity and usability of low-cost accelerometers for internet-based self-monitoring of physical activity in patients with chronic obstructive pulmonary disease. Interact. J. Med. Res. 3(4), e14 (2014).
Prieto-Centurion, V. et al. Can commercially available pedometers be used for physical activity monitoring in patients with COPD following exacerbations?. Chronic Obstr. Pulm. Dis. 3(3), 636–642 (2016).
Cheng, S. L. et al. Comparison between COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) dyspnea scores for evaluation of clinical symptoms, comorbidities and medical resources utilization in COPD patients. J. Formos Med. Assoc. 118(1 Pt 3), 429–435 (2019).
Ozben, B. et al. Acute exacerbation impairs endothelial function in patients with chronic obstructive pulmonary disease. Turk. Kardiyol. Dern. Ars. 38(1), 1–7 (2010).
Sproston, N. R. & Ashworth, J. J. Role of C-reactive protein at sites of inflammation and infection. Front. Immunol. 9, 754 (2018).
Venugopal, S. K., Devaraj, S., Yuhanna, I., Shaul, P. & Jialal, I. Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 106(12), 1439–1441 (2002).
Vivodtzev, I. et al. Arterial stiffness in COPD. Chest 145(4), 861–875 (2014).
Stickland, M. K. et al. Chemosensitivity, cardiovascular risk, and the ventilatory response to exercise in COPD. PLoS ONE 11(6), e0158341 (2016).
Edgell, H., Moore, L. E., Chung, C., Byers, B. W. & Stickland, M. K. Short-term cardiovascular and autonomic effects of inhaled salbutamol. Respir. Physiol. Neurobiol. 231, 14–20 (2016).
Moore, L. E. et al. Acute effects of salbutamol on systemic vascular function in people with asthma. Respir. Med. 155, 133–140 (2019).
Demeyer, H. et al. The minimal important difference in physical activity in patients with COPD. PLoS ONE 11(4), e0154587 (2016).
Moore, L. E. et al. Cardiovascular benefits from standard pulmonary rehabilitation are related to baseline exercise tolerance levels in chronic obstructive pulmonary disease. Respir. Med. 132, 56–61 (2017).