1. Menzies-Gow A, et al. An expert consensus framework for asthma remission as a treatment goal. J Allergy Clin Immunol. 2020;145(3):757-765.
2. AstraZeneca plc. H1 and Q2 2023 Results Presentation. Available at: www.astrazeneca.com/content/dam/az/PDF/2023/h1/H1-and-Q2-2023-results-announcement.pdf. [Last accessed: August 2023].
3. Jackson D, et al. SHAMAL: Reduction of Maintenance Inhaled Corticosteroids in Patients with Severe Eosinophilic Asthma Treated with Benralizumab: A Randomised Phase 4 Study. [Oral Presentation]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
4. Lommatzsch, M, et al. Durability of Benralizumab-induced remission in severe asthma: an analysis of the BORA study [Oral Presentation]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
5. Pelaia, G, et al. Patients with severe eosinophilic asthma achieved remission over 2 years with benralizumab: Integrated analysis of the >1000-patient, multinational, real-world XALOC-1 study [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
6. Lai, K, et al. Efficacy and safety of benralizumab in patients with severe uncontrolled asthma despite ICS-LABA: a randomised, double-blind, placebo-controlled phase 3 trial in Asia (MIRACLE) [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
7. Huang K, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019; 394: 407-418.
8. AstraZeneca plc. H1 and Q2 2023 Results Clinical Trials Appendix. Available at: www.astrazeneca.com/content/dam/az/PDF/2023/h1/H1-and-Q2-2023-results-clinical-trials-appendix.pdf. [Last accessed: August 2023].
9. Wechsler, ME, et al. On-treatment clinical remission with tezepelumab in patients with severe, uncontrolled asthma in the phase 3 DESTINATION study [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
10. Brightling, C, et al. Biomarkers and clinical outcomes after cessation of tezepelumab after 2 years of treatment (DESTINATION) [Oral Presentation]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
11. Vogelmeier, C, et al. Increased risk of severe cardiovascular events following exacerbations of COPD: a multi-database cohort study [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
12. GOLD. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD), 2023. [Online]. Available at: goldcopd.org. [Last accessed: August 2023]
13. Wilkinson, T, et al. Tozorakimab in patients hospitalised with COVID-19: a phase 2, randomised adaptive platform study (ACCORD-2) [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
14. England E, et al. Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction. Sci Rep. 2023 Jun 17;13(1):9825.
15. Stephenson, K, et al. Development of a huPCLS platform to explore IL-33 biology and test novel therapies [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
16. Ritchie, AI, et al. Characterising radiological abnormalities in Early COPD [Poster Session]. Presented at the European Respiratory Society (ERS) International Congress 2023 (9-13 September).
17. Chung, KF, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014 Feb;43(2):343-73.
18. The Global Asthma Network. The Global Asthma Report 2022. Available at: globalasthmareport.org/resources/Global_Asthma_Report_2022.pdf. [Last accessed: August 2023.]
19. Wenzel S. Severe asthma in adults. Am J Respir Crit Care Med. 2005;172:149-60.
20. Fernandes AG, et al. Risk factors for death in patients with severe asthma. J Bras Pneumol. 2014; 40: 364-372.
21. Peters SP, et al. Uncontrolled asthma: a review of the prevalence, disease burden and options for treatment. Respir Med 2006;100(7):1139-51.
22. World Health Organization. The Top 10 Causes of Death. Accessible at: www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death. [Last accessed: August 2023].
23. Adeloye D, et al. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. (2022) Vol 10(5); 447-458.
24. AstraZeneca. Fasenra Summary of Product Characteristics. Available at: www.ema.europa.eu/en/documents/product-information/fasenra-epar-product-information_en.pdf. [Last accessed: August 2023].
25. Corren J, et al. Tezepelumab in adults with uncontrolled asthma [supplementary appendix; updated April 18, 2019]. N Engl J Med. 2017;377:936-946.
26. Varricchi G, et al. Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer. Front Immunol. 2018;9:1595.
27. AstraZeneca plc. Tezspire (tezepelumab) approved in the US for severe asthma. Available at: www.astrazeneca.com/media-centre/press-releases/2021/tezspire-tezepelumab-approved-in-the-us-for-severe-asthma.html. [Last accessed: August 2023].
28. AstraZeneca plc. Tezspire approved in the EU for the treatment of severe asthma. 2022. Available at: www.astrazeneca.com/media-centre/press-releases/2022/tezspire-approved-in-the-eu-for-the-treatment-of-severe-asthma.html. [Last accessed: August 2023].
29. AstraZeneca plc. Tezspire approved in Japan for the treatment of severe asthma. Available at: www.astrazeneca.com/media-centre/press-releases/2022/tezspire-approved-in-japan-for-severe-asthma.html. [Last accessed: August 2023].
