Medium-term creatine supplementation appears to reduce general fatigue and other conditions related to post-Covid-19 fatigue syndrome such as loss of sense of taste, breathing difficulties, body aches, headache, and difficulties concentrating, according to research published in Food Science & Nutrition.

The study, which examined young-to-middle-aged adults suffering from moderate post-Covid-19 fatigue syndrome, analyzed patient- and clinician-reported outcomes when administering 4 g of creatine monohydrate per day to six patients for six months.

The researchers found supplementation significantly improved patient scores for several post-Covid-19 fatigue syndrome-related symptoms, including a compelling drop in lung and body pain after the intervention.

The creatine was provided to patients by Alzchem GmbH. Participants were asked to refrain from using any other dietary supplements and to keep a regular diet during the trial. 

Brain connection

Post-viral fatigue syndrome (PVFS), which is not only limited to Covid-19, is a perplexing long-term neurological disorder, formerly known as chronic fatigue syndrome or myalgic encephalomyelitis, the researchers said. PVFS may mean the inability to participate in routine activities that were possible before becoming ill, lasting for more than six months, and accompanied by fatigue, post-exertional malaise, and unrefreshing sleep.

“We found that creatine significantly increased total creatine levels in several locations across the brain (also a skeletal muscle), with an increase up to 33% (for the right parietal white matter),” the scientists said.

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