Simona Halep, a former champion, suffered panic attacks mid-match after losing her second round match at the French Open.
The 30-year old appeared to be having breathing problems and called the trainer during Zheng Qinwen's 2-6 6-2 6-1 defeat.
Halep, 2018 winner, was another big name that was knocked out on an eventful day at Roland Garros.
In Paris, however, Iga Swiatek, the world number one, defeated another opponent.
Swiatek (20) is one of three top-10 female singles seeds left after the first two rounds. She joins Spanish third seed Paula Badosa (Spanish) and Aryna Sabalenka (Belarus).
Halep was physically exhausted in the second match against her 19 year-old opponent. Zheng won the second set and Halep lost the last 12 games.
Halep, a two-time Grand Slam champion, had led by a set & a break but claimed she didn't know how to deal with the situation after a rare panic attack.
Halep stated, "I don’t have it often." "I don’t know why it happened because I was leading that match. I was playing well.
"But it just happened, and as I stated, it was a complete accident. She added that she couldn't concentrate.
"After the match, it was quite difficult but now I feel good. I am now fully recovered and will take this episode as a learning experience.
"It wasn't dangerous to me, but it happened." It's great that I can now smile.
Halep's defeat was the latest high-profile loss in the women’s draw.
The upset of the day was against Wimbledon runner up Karolina Pliskova who was shocked 6-2 6-2 by French number 227 Leoliajean.
On Thursday, Ninth seed Danielle Collins lost 6-4 to Shelby Rogers, a fellow American.
Swiatek can't be stopped at Roland Garros.
Swiatek was unaffected by these problems, however, and it is becoming more difficult to answer the question who could stop Swiatek from being the top seed at this year's French Open.
The 2020 champion defeated another opponent to win a quick victory that took her into the third round of Roland Garros.
Swiatek won 6-0 6-2 against American Alison Riske in just 61 minutes.
Swiatek won her opener in 54 minutes against Lesia Tsurenko from Ukraine. She now has 30 wins and is looking for her sixth title.
Swiatek said that she feels like she's using her new position to exert more pressure on my rivals. Swiatek became the world number one after Ashleigh Barty's shocking retirement in March.
"I am very happy that I was able to convert it into a way that is really useful. My confidence has improved."