rivaroxaban and sertraline.docx – Brand Name Xarelto Generic Rivaroxaban Brand Name Zoloft Generic Sertraline Classification Anticoagulants

Generic:
Rivaroxaban
Brand Name: Xarelto
Classification:
Anticoagulants, antithrombotic, factor Xa inhibitors
Therapeutic use:
Prevention, treatment of, and reduction of deep vein thrombosis
that may lead to pulmonary embolism following knee or hip replacement surgery.
Reduction in risk of stroke
Action:
Acts as selective factor X inhibitor that blocks the active site of factor Xa,
inactivating the cascade of coagulation.
Safe dosage:
10 mg once daily, initiated 6-10 hr post-op, continued for 35 days or 12
days after knee replacement; 20 mg once daily with evening meals for reduction in risk
of stroke.
Onset:
unknown
Peak:
2-4 hr
Duration:
24 hr
Patient teaching:
To report any symptoms of unusual bleeding or bruising (bleeding
gums, nosebleed, black tarry stool, hematuria, excessive menstrual flow) symptoms of
spinal or epidural hematoma (tingling, numbness, especially in lower extremities,
muscular weakness)
Adverse Effects:
CNS: syncope. DERM: blister, pruritus. HEMA: bleeding LOCAL: