Brand Name: Xarelto
Anticoagulants, antithrombotic, factor Xa inhibitors
Prevention, treatment of, and reduction of deep vein thrombosis
that may lead to pulmonary embolism following knee or hip replacement surgery.
Reduction in risk of stroke
Acts as selective factor X inhibitor that blocks the active site of factor Xa,
inactivating the cascade of coagulation.
10 mg once daily, initiated 6-10 hr post-op, continued for 35 days or 12
days after knee replacement; 20 mg once daily with evening meals for reduction in risk
To report any symptoms of unusual bleeding or bruising (bleeding
gums, nosebleed, black tarry stool, hematuria, excessive menstrual flow) symptoms of
spinal or epidural hematoma (tingling, numbness, especially in lower extremities,
CNS: syncope. DERM: blister, pruritus. HEMA: bleeding LOCAL: