by Anneke Klomp
1. MOA: accelerates ability of antithrombin to active coag->
1.1. prevents thrombus prop by facilitating fibrinolysis BUT does not lyse existing thrombi
2. unfractionated
2.1. short half life (rapid anticoag)
2.2. tx of DVT/PE; prophylaxis for VTE; acute coronary syndrome
2.3. safe in pregnancy
2.4. variable dosing ->
2.4.1. adjust dosage according to aPTT
2.5. AE: bleeding (more c in elderly women); reversal agent is IV protamine sulfate; GI; thrombocytopenia (HIT)
3. low molecular weight
3.1. dalteparin; enoxaparin; tinzaparin
3.2. prophylaxis AND tx for DVT and PE
3.3. enoxaparin tx ACS
3.4. predictable dose
3.4.1. no lab monitoring