22Dec ch 90 Flashcards | Quizlet Posted by: admin Categories: Pneumonia Comments Off on ch 90 Flashcards | Quizlet ch 90 Flashcards | Quizlet -none of these drugs are given alone-isoniazid (primary treatment and prophylaxis of TB)-rifampin (combined with isoniazid before resistance is seen)-rifapentine (long-acting version of rifampin)-rifabutin (used for patients with HIV patients because it effects metabolism less)-pyrazinamide (used for drug- sensitive TB with many other drugs)-ethambutol (only active against mycobacteria) goals of first-line TB drugs -goals of treatment are to eliminate infection and prevent relapse while preventing the development of drug-resistant organisms fluoroquinolone use (ciproflaxin) -used to treat severe bacterial infections-also disrupts DNA replication and cell division side effects of fluoroquinolone (ciproflaxin) -GI (nausea/ vomiting, diarrhea, abdominal pain)- CNS (dizziness, headache, restlessness, confusion, rarely seizures)- tendon rupture in the Achilles (low risk)- phototoxicity- candida infections in the pharynx and vagina- increase risk of c. diff infectionprolongs QT interval risks/ percautions for fluoroquinolone (ciproflaxin) - avoid giving to patients over 60-avoid in patients under 18yrs-avoid in patients who have undergone kidney, heart, or lung transplantation risks for older patients fluoroquinolone (ciproflaxin) - confusion, somnolence (drowsiness), psychosis, visual disturbances-myasthenia travis (weakening of the muscles; can worsen or exacerbate symptoms) interactions with fluoroquinolone (ciproflaxin) - cationic compounds (absorption is reduced by them)- elevation of drug levels for theophylline, warfarin, tinidazole used to treat protozoal infections caused by obligate anaerobes, h. pylori, and c. diff metronidazole side effects - neurotoxicity- allergy- superinfection metronidazole interactions - do not mix with alcohol (will cause disulfiram reaction; like a hangover) } Source link
