Musk, 51, offered up the match after commenting under a post about Zuckerberg's newest suspected project, which will reportedly be called Threads and rival Twitter.
'I'm sure Earth can't wait to be exclusively under Zuck's thumb with no other options. At least it will be 'sane.' Was worried there for a moment,' Musk commented.
Zuckerberg replied on his Instagram story, sharing a screenshot of Musk's challenge, writing: 'Send me location.'
Elon Musk (right) has challenged jiu-jitsu-trained Mark Zuckerberg to a 'cage match' after making a backhanded comment about Meta's reported new development Threads that is suspect to rival Twitter. Musk has trained in Kyokushin karate, taekwondo, judo, and 'Brazilian jiu-jitsu briefly' throughout his life
Zuckerberg replied on his Instagram story, sharing a screenshot of Musk's challenge, writing: 'Send me location.' The Meta CEO recently placed a jiu-jitsu tournament in May
Musk has trained in Kyokushin karate, taekwondo, judo and 'Brazilian jiu-jitsu briefly' throughout his life, he revealed on Joe Rogan's podcast, and he's shared a photo of himself fighting a sumo wrestler in the past.
However, Musk might not find the match to be as easy as he thinks as the Meta CEO, recently placed in a jiu-jitsu tournament in May.
'Maybe to some degree, your ability to keep doing interesting things is your willingness to be embarrassed again and go back to step one and start as a beginner, and get your ass kicked,' Zuckerberg said on a podcast earlier this year.
Earlier this month, Zuckerberg bashed a New York Times report claiming he was knocked out during a Jiu-Jitsu fight after a referee ended the bout early and gave the win to an opponent.
A clip of him wrestling on the floor and trying to break free from an opponent who pinned him down on the mat went viral.
They struggled for more than a minute before Zuckerberg was locked in a submission and the referee called the match, giving the win to his opponent.
The official said he stopped the fight because he heard the tech CEO snoring and thought he had passed out during the chokehold.
But Zuckerberg and his coach Dave Camarillo told the publication he had not lost consciousness and the referee mistook his grunting for snoring.
'That never happened,' Zuckerberg wrote in an email.
The interaction began after Musk commented about the Meta's reported in-development app, saying: 'I'm sure Earth can't wait to be exclusively under Zuck's thumb with no other options'
Meta Chief Product Officer Chris Cox commented on the company's upcoming text-based app, referring to it as 'our response to Twitter,' the Verge reported earlier this month.
The app reportedly has a host of celebrities joining it, including Oprah and Dalai Lama.
DailyMail.com has reached out to Meta for comment.
Last year, Musk challenged Vladimir Putin to 'single combat.'
'I hereby challenge Vladimir Putin to single combat,' Musk tweeted in March 2022, typing Putin's name in Russian. 'Stakes are Ukraine,' he added, writing the country's name in Ukrainian.
Before winning his tournament, Zuckerberg admitted he had to 'get your ass kicked' while learning the fighting style
Musk capped off his challenge with a direct reference to the Kremlin.
'Do you agree to this fight?' he wrote at the time, tagging the Kremlin's official Twitter account.
The South African-born billionaire, who has been known for making outlandish comments on Twitter in the past, was perhaps biting off more than he can chew in challenging the former head of the KGB.
The Russian president is a judo blackbelt and co-authored a book about the sport, titled 'Judo: History, Theory, Practice.'
Putin, 69, was made honorary president of the International Judo Federation in 2008 but has been suspended from the role over the war on Ukraine.