Many medications have the potential to bring side effects, and fluticasone is no exception. Fortunately, more common side effects from fluticasone aren't usually very severe, and they typically only affect your nose and throat. For instance, some of the most common side effects are a sore throat, bloody nose, and a stuffy or runny nose. Some people may also experience more sinus-focused problems, like puffiness or tenderness in the cheeks or under their eyes, and headaches.
Also commonly reported are tightness in the chest, muscle aches, difficulty breathing, fatigue, and an overall feeling of weakness. Some people might also have stomach upset or vomiting after taking fluticasone, regardless of whether they use the nasal spray or inhaled version.
Although these side effects are the most common ones reported for fluticasone, you should still be sure to tell your doctor if you experience any of them, especially if they interfere with your everyday life. Your doctor might decide that lowering your dosage or switching you to a different medication is a better solution for you.