BRAND NAME GENERIC NAME CLASSIFICATIONPRESCRIBED AND RECOMMENDED DOSAGE, FREQUENCY, ROUTE OF  ADMINISTRATIONMECHANISM OF  ACTIONINDICATIONCONTRAINDICATION ADVERSE REACTIONNURSING RESPONSIBILITIESGENERIC NAME: Heparin SodiumBRAND NAME: Hepalean, Heparin Sodium Lock flush solution, Hep-Lock, Lipo-Hepin, Liquaemin SodiumCLASSIFICATION: Blood formers, coagulators, and anticoagulants AnticoagulationIntermittent IV injection8000-10,000 units IV initially, THEN 50-70 units/kg (5000-10,000 units) q4-6hr Continuous IV infusion5000 units IV injection, followed by continuous IV infusion of 20,000-40,000 units/24 hr Dosing considerationsNumerous concentrations Stimulates beta2 -adrenergic receptors in lungs, resulting in relaxation of bronchial smooth muscle.Therapeutic Effect: Relieves bronchospasm and reduces airway resistance.Prevention and treatment of venous thrombosis and pulmonary embolism.Treatment of atrial fibrillation with embolization•Diagnosis and treatment of DIC•Prevention of clotting in blood samples and heparinlock sets and during dialysis procedures•Unlabeled uses:  Adjunct in therapy of coronary occlusion with acute MI,prevention of left ventricular thrombi and CVA post-MI, hypersensitivity to heparin; severe thrombocytopenia;uncontrolled bleeding; any patient who cannotbe monitored regularly with bloodcoagulation tests; labor and immediate postpartum period;women older than 60 yr are at high risk for hemorrhaging.

Use cautiously

 with pregnancy; dysbetalipoproteinemia; recent surgery or injuryHeparin-induced thrombocytopenia, possibly delayed (10-30% )Frequency Not DefinedMild painHemorrhageInjection site ulcer (after deep SC injection)Increased liver aminotransferase

Assessment & Drug Effects

Lab tests: Baseline blood coagulation tests, Hct, Hgb, RBC, and platelet counts prior to initiation of therapy and at regular intervals throughout therapy.Monitor APTT levels closely.Note: In general, dosage is adjusted to keep APTT between 1.5–2.5 times normal control level.Draw blood for coagulation test 30 min before each scheduled SC or intermittent IV dose and approximately q4h for patients receiving continuous IV heparin during dosage adjustment period.  After dosage is established, tests may be done once daily.Patients vary widely in their

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