Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population

Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population

ประเภทเอกสาร

บทความในวารสาร

10.1016/j.archoralbio.2011.10.009

ชื่อวารสาร

ฉบับที่/หน้า

ปีที่ 57 ฉบับที่ 5 หน้า 491-494

วารสารออนไลน์:

ดรรชนี-อังกฤษ

Interferon-γ;Oral lichen planus;Polymorphism;gamma interferon;allele;article;case control study;chi square distribution;female;gene frequency;genetic predisposition;genetics;genotype;human;lichen planus;male;middle aged;polymerase chain reaction;single nucleotide polymorphism;Thailand;Alleles;Case-Control Studies;Chi-Square Distribution;Genetic Predisposition to Disease;Humans;Interferon-gamma;Lichen Planus, Oral;Polymorphism, Single Nucleotide

Objective: Interferon-gamma (IFN-γ) is highly expressed in oral lichen planus (OLP). The IFN-γ (+874 in intron 1, rs2430561) TT genotype, which has been reported to be associated with high IFN-γ production, was hypothesized to be associated with susceptibility to OLP in the Thai population. Design: Genomic DNA samples from 74 OLP and 268 healthy controls were evaluated for IFN-γ polymorphisms by polymerase chain reaction with sequence-specific primers (PCR-SSP) and direct sequencing method. Results: The T allele was significantly associated with an increased risk of OLP development as compared to the A allele (OR = 1.76, P = 0.004; P c = 0.02). The effect of the T allele was similar to an autosomal recessive disorder; the presence of TT genotype (when compared to AA and AT) conferred an OR of 2.61, P = 0.008; P c = 0.04. Conclusions: We found an association between IFN-γ +874A/T polymorphism and susceptibility to OLP. However, an association study utilising a larger sample size and patients from other races apart from the Asian population should be performed to further verify these findings. © 2011 Elsevier Ltd.

ผู้แต่ง (สังกัด)

[1] Kimkong, I.
[2] Nakkuntod, J.
[3] Sodsai, P.
[4] Hirankarn, N.
[5] Kitkumthorn, N.

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