Clinical MedicineIn-Press PreviewVirology

Free access | 10.1172/JCI151697


Ravindra Ganesh,1


Colin F. Pawlowski,2


John C. O'Horo,3


Lori L. Arndt,4


Richard F. Arndt,5


Sarah Bell,6


Dennis M. Bierle,1


Molly Destro Borgen,7


Sara Hanson,8


Alexander Heyliger,9


Jennifer L. Larsen,6


Patrick J. Lenehan,10


Robert Orenstein,11


Arjun Puranik,2


Leigh L. Speicher,12


Sidna M. Tulledge-Scheitel,13


AJ Venkatakrishnan,2


Caroline G. Wilker,14


Andrew D. Badley,3 and


Raymund R. Razonable15

1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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Destro Borgen, M.
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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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Speicher, L.
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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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1Department of General Internal Medicine, Mayo Clinic, Rochester, United States of America

2Data Sciences, nFerence, Cambridge, United States of America

3Mayo Clinic, Rochester, United States of America

4Department of Infectious Diseases, Mayo Clinic Health Systems, Eau Claire, United States of America

5Department of Pharmacy, Mayo Clinic Health Systems, Eau Claire, United States of America

6Department of Nursing, Mayo Clinic, Rochester, United States of America

7Administration, Mayo Clinic, Rochester, United States of America

8Family Medicine, Mayo Clinic Health Systems, Mankato, United States of America

9Department of Pharmacy, Mayo Clinic, Rochester, United States of America

10nFerence, Cambridge, United States of America

11Department of Infectious Diseases, Mayo Clinic Arizona, Scottsdale, United States of America

12Department of General Internal Medicine, Mayo Clinic Florida, Jacksonville, United States of America

13Department of Community Internal Medicine, Mayo Clinic, Rochester, United States of America

14Department of Internal Medicine, Mayo Clinic Health Systems, La Crosse, United States of America

15Department of Infectious Diseases and Transplant Virology, Mayo Clinic, Rochester, United States of America

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Published August 19, 2021
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Abstract

BACKGROUND. Clinical data to support the use of bamlanivimab for the treatment of outpatients with mild to moderate coronavirus disease-19 (COVID-19) is needed.

METHODS. 2,335 patients who received single-dose bamlanivimab infusion between November 12, 2020 to February 17, 2021 were compared with a propensity-matched control of 2,335 untreated patients with mild to moderate COVID-19 at Mayo Clinic facilities across 4 states. The primary outcome was the rate of hospitalization at days 14, 21 and 28.

RESULTS. The median age of the population was 63; 47.3% of the bamlanivimab-treated cohort were ≥65 years; 49.3% were female. High-risk characteristics included hypertension (54.2%), body mass index ≥35 (32.4%), diabetes mellitus (26.5%), chronic lung disease (25.1%), malignancy (16.6%), and renal disease (14.5%). Patients who received bamlanivimab had lower all-cause hospitalization rates at days 14 (1.5% vs 3.5%; Odds Ratio [OR], 0.38), 21 (1.9% vs 3.9%; OR, 0.46), and 28 (2.5% vs 3.9%; OR, 0.61). Secondary exploratory outcomes included lower intensive care unit admission rates at days 14 (0.14% vs 1%; OR, 0.12), 21 (0.25% vs 1%; OR: 0.24) and 28 (0.56% vs 1.1%; OR: 0.52), and lower all-cause mortality at days 14 (0% vs 0.33%), 21 (0.05% vs 0.4%; OR,0.08) and 28 (0.11% vs 0.44%; OR, 0.01). Adverse events were uncommon with bamlanivimab, occurring in 19/2355, most commonly fever (n=6), nausea (n=5), and lightheadedness (n=3).

CONCLUSIONS. Among high-risk patients with mild to moderate COVID-19, treatment with bamlanivimab was associated with a statistically significant lower rate of hospitalization compared with usual care.

FUNDING. Mayo Clinic. 

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