% of patients requiring mechanical ventilation |
42 |
34 |
49 |
Triangular |
[8, 12, 13, 15] |
Days of hospitalization for nonventilated patients |
15 |
5 |
18 |
Triangular |
|
Days of hospitalization for ventilated patients |
19 |
13 |
32 |
Triangular |
|
Efficacy |
Base |
Low |
High |
Distribution |
Source |
Reduced days of hospitalization with remdesivir (from 15 days to 10 days) |
5 |
1 |
9 |
Triangular |
[14, 15] |
Mortality if those additional patients receive ICU care, % |
50 |
40 |
85 |
Beta |
[12] |
Mortality if those additional patients do not receive ICU care, % |
90 |
85 |
100 |
Beta |
[12] |
Mortality rate reduction for earlier stage (nonventilated) patients due to remdesivir, % |
0 |
0 |
70 |
Beta |
[14, 15] |
Mortality rate reduction for later stage (ventilated) patients due to dexamethasone, % |
35 |
18 |
49 |
Beta |
[8] |
Mortality rate reduction for earlier stage (nonventilated) patients due to dexamethasone, % |
20 |
8 |
30 |
Beta |
[8] |
Cost inputs |
USD |
Low |
High |
Distribution |
Source |
Health system operation cost in ICU per person day, $ |
1128 |
665 |
1172 |
Gamma |
[15] |
Cost of remdesivir regimen (200-mg IV loading dose followed by 100 mg IV daily for a maximum of 5 days), $ |
330 |
99 |
400 |
Gamma |
[17] |
Cost of dexamethasone regimen (6 mg PO/IV for up to 10 days), $ |
31 |
16 |
47 |
Gamma |
[18] |
Source link