Drug-Drug Interaction: ZOLPIDEM+MELATONIN may have interaction with high blood pressure-lowering medicines (metoprolol), opioid pain killers (hydrocodone, oxycodone, naloxone, tramadol), antidepressants (sertraline, desipramine, fluoxetine, venlafaxine, bupropion, fluvoxamine, escitalopram, amitriptyline, citalopram, duloxetine, mirtazapine), antibiotics (ciprofloxacin, rifampicin), antifungal drugs (ketoconazole), anti-anxiety drugs (alprazolam, clonazepam, lorazepam), antiallergics/antihistamines (diphenhydramine, hydroxyzine), muscle relaxants (cyclobenzaprine), antiepileptic drugs (gabapentin, pregabalin), stomach ulcer medicines (cimetidine), hypnotics (midazolam, temazepam, zaleplon).
Drug-Food Interaction: ZOLPIDEM+MELATONIN may interact with caffeine, St John’s wort (herbal medicine for treating depression) and may reduce the effectiveness of ZOLPIDEM+MELATONIN. Also, avoid alcohol intake as it may increase the risk of dependence, psychomotor impairment (slowdown of thought process, and reduced physical movements), sleepwalking, or sleep-driving.
Drug-Disease Interaction: Do not take ZOLPIDEM+MELATONIN if you have severe liver disease, breathing problems, sleep apnoea (sudden stopping of breathing during sleep), severe muscle weakness, diabetes, kidney problems, any history of depression or mental illness.
