18Dec Hematologic Flashcards | Quizlet Posted by: admin Categories: Pulmonary Embolism Comments Off on Hematologic Flashcards | Quizlet Hematologic Flashcards | Quizlet heparinwarfarin Factor Xa inhibitors -Myocardial infarction-ischemic stroke-DVT/PE-atrial fibrillation -after surgery-extended immobilization -treat DVT-MOA: increase antithrombin activity which binds and inactivates clotting factors (thrombin, IXa, Xa)-IV or injection: rapid onset -MUST monitor INR, partial thromboplastin, and platelets -side effects: bleeding (thrombocytopenia) -treat long term prevention of DVT and treat a-fib-MOA: interferes with vitamin K metabolism in the live= impaired hepatic synthesis of clotting factors -can rapidly reverse-MUSt monitor INR, prothrombin (narrow therapeutic index)-side effects: bleeding, leafy greens high in vit K -treat DVT and a-fib-MOA: directly inhibits/inactivates clotting factor Xa by binding and activating antithrombin-cannot rapidly reverse -No INR monitoring needed -side effects: bleeding -prevent atrial and venous clots -MOA: inhibits synthesis of prostaglandins and thromboxanes (which cause platelet aggregation)-low dose: largely effective-side effects: GI upset, bleeding t-PA (tissue plasminogen activator) -treat acute MI, acute ischemic CVA, -MOA: breakdown clots via activation of plasmin to break down fibrin-IV, rapid onset -door to needle 1-3 hours -side effects: bleeding } Source link
Week 6 Pre-lab Assignment.docx – Week 6 Pre-lab Assignment Directions Along with answering each question below provide a supporting rationale for it The