Patent no. Country of filing Composition/active ingredient Major outcome Publication/grant year Ref.
8926991 USA Botulinum toxin For treating primary disorders of mood and affect with a neurotoxin, including depression, nervousness, and sleep disorders. 2015 [191] US 8252809B2 USA Zolpidem Solid dosage form for treating midnight insomnia by administration of low doses (5 mg or less) of zolpidem or a salt thereof. 2012 [192] US 8242131B2 USA Zolpidem Methods and compositions for treatment of midnight insomnia by administration of low doses (5 mg or less) of zolpidem or a salt thereof. 2012 [193] US 8148393B2 USA Zolpidem A modified release zolpidem tablet is designed as a tablet-in-tablet dosage form. 2012 [194] US 8034371 B2 USA Zolpidem Intranasal solutions of zolpidem for the prevention/treatment of insomnia or the therapy of neurological diseases. 2011 [195] US 7914826 USA Combination containing melatonin and other herbal supplements Supplemental compositions and methods for inducing a restful night’s sleep by rapidly inducing a person to fall asleep and to maintain sleep. 2011 [196] US 7906154 USA Combination containing melatonin and other herbal supplements Supplemental compositions and methods for inducing a restful night’s sleep by rapidly inducing a person to fall asleep and to maintain sleep. 2011 [197] US 7655681B2 USA Zonisamide For treatment or prevention of obstructive sleep apnea (OSA) by the administration of a pharmacologically effective amount of zonisamide to a patient 2010 [198] US 7632517B2 USA Zolpidem Zolpidem containing buccal aerosol sprays or capsules for faster absorption through the oral mucosa, leading to faster onset of effect for insomnia. 2009 [199] US 6998112B2 USA Sleep-inducing natural herb or hormone A toothpaste for inducing sleep while simultaneously promoting intraoral cleanliness, which includes toothpaste base ingredients and at least one sleep-inducing natural herb or hormone and these are selected from the group consisting of chamomile, lemon balm, passion flower, and valerian, and the hormone melatonin. 2006 [200] US 6703412 B1 USA Melatonin A method of treating sleeplessness in humans by administering an effective sleep-inducing amount of not greater than about 5 mg of melatonin 2004 [201]

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