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Pulmonary Tuberculosis

27Aug

Outcome Improvements With Ixazomib and Dexamethasone in Relapsed or Refractory Systemic Light Chain Amyloidosis

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Results of an interim analysis of the phase 3 TOURMALINE-AL1 study (ClinicalTrials.gov Identifier: NCT01659658), comparing ixazomib and dexamethasone vs physician’s choice of treatment in relapsed or refractory systemic light chain (AL) amyloidosis, were recently reported in the journal Leukemia. Although ixazomib and dexamethasone did not significantly increase overall hematologic response rate relative to physician’s choice […]

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25Aug

Increased Risk of Death Reported in Pepaxto Confirmatory Trial

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The Food and Drug Administration (FDA) is alerting health care professionals that the use of Pepaxto® (melphalan flufenamide) in combination with dexamethasone to treat patients with multiple myeloma may increase the risk of death following results from a confirmatory phase 3 trial. Pepaxto is a peptide conjugated alkylating drug that is highly lipophilic, which allows […]

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25Aug

Combined Therapy of Ciclosporin Plus Favipiravir in the Management of Patients with Severe COVID-19, not Responding to Dexamethasone: A non-Controlled Prospective Trial

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This article was originally published here Int Immunopharmacol. 2021 Aug 4;99:108043. doi: 10.1016/j.intimp.2021.108043. Online ahead of print. ABSTRACT BACKGROUND: Regarding the COVID-19 pandemic, potential therapeutic agents are being evaluated almost every day. Ciclosporin, a calcineurin inhibitor, is characterized by beneficial antiviral and immunomodulatory effects. The present study aimed to evaluate the efficacy of ciclosporin in […]

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25Aug

Dexamethasone Studied for Treatment of Heavy Menstrual Bleeding

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WEDNESDAY, Aug. 18, 2021 (HealthDay News) — Low-dose dexamethasone may reduce heavy menstrual bleeding (HMB) when taken during the luteal phase of menstrual cycles, according to a study published online recently in EBioMedicine. Pamela Warner, Ph.D., from the University of Edinburgh in the United Kingdom, and colleagues randomly assigned 97 women with HMB to placebo […]

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25Aug

An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer

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This article was originally published here Pharmacol Res Perspect. 2021 Oct;9(5):e00845. doi: 10.1002/prp2.845. ABSTRACT Dexamethasone has antitumor activity in metastatic castration resistant prostate cancer (mCRPC). We aimed to investigate intravenous liposome-encapsulated dexamethasone disodium phosphate (liposomal dexamethasone) administration in mCRPC patients. In this exploratory first-in-man study, patients in part A received a starting dose of 10 […]

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25Aug

Using Ruxolitinib to Target JAK1/2 in T-LBL May Prevent Treatment Resistance

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For pediatric patients with T-cell origin lymphoblastic leukemia (T-LBL) with disease progression following second-line treatment, investigators found that the JAK1/2 pathway may be a new actionable target through treatment with ruxolitinib. For the approximate 14% of pediatric patients with T-cell origin lymphoblastic leukemia (T-LBL) with disease progression following second-line treatment, investigators from Italy have found […]

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25Aug

Carfilzomib and dexamethasone induction with lenalidomide, clarithromycin and dexamethasone consolidation and lenalidomide maintenance for newly diagnosed multiple myeloma

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This article was originally published here Am J Hematol. 2021 Aug 23. doi: 10.1002/ajh.26329. Online ahead of print. ABSTRACT Combination treatment regimens including a proteasome inhibitor (PI), an immunomodulatory agent (IMiD) and a corticosteroid are standards of care for initial treatment of multiple myeloma (MM). We aimed to evaluate if a sequential treatment program using […]

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25Aug

‘Don’t take dexamethasone without medical advice’

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Doctors warn public of dire consequencesReports of home-based Covid-19 patients ingesting drug orally BY Pamodi Waravita The Sri Lanka Medical Association (SLMA) yesterday (24) cautioned patients undergoing home treatment for Covid-19 and their caregivers against the medically unsupervised use of dexamethasone, as it could lead to severe health issues. The SLMA said that such medically […]

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19Aug

Anakinra Deemed Safe, Anti-inflammatory Drug for Patients With COVID-19

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Anakinra treatment may reduce mortality risk in patients with moderate-to-severe COVID-19, according to a study published in The Lancet.1 The safe, anti-inflammatory treatment is especially useful when patients present symptoms of hyperinflammation. “This study is, to our knowledge, the first patient-level meta-analysis to analyses the effects of anakinra treatment in patients admitted to hospital with […]

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19Aug

COVID-19 Scan for Aug 18, 2021

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Refugees’ mental health affected by COVID-19 stressors For refugees, the biggest predictor of post-traumatic stress disorder (PTSD), health anxiety, depression, or disability during COVID-19 was if their pandemic experiences triggered memories of past trauma, according to survey results published today in the European Journal of Psychotraumatology. The researchers surveyed 656 adult refugees in Australia (average […]

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19Aug

Dexamethasone Studied for Treatment of Heavy Menstrual Bleeding – Consumer Health News

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WEDNESDAY, Aug. 18, 2021 (HealthDay News) — Low-dose dexamethasone may reduce heavy menstrual bleeding (HMB) when taken during the luteal phase of menstrual cycles, according to a study published online recently in EBioMedicine. Pamela Warner, Ph.D., from the University of Edinburgh in the United Kingdom, and colleagues randomly assigned 97 women with HMB to placebo […]

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19Aug

UN agency donates COVID-19 medicine to BiH

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SARAJEVO, Aug. 18 (Xinhua) — United Nations Children’s Fund (UNICEF) delivered Dexamethasone drug worth 1 million U.S. dollars to Bosnia and Herzegovina (BiH), said the Ministry of Civil Affairs of BiH on Wednesday. According to the World Health Organization, Dexamethasone, a common steroid, has had a beneficial effect on patients severely ill with COVID-19. Since […]

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18Aug

Health Highlights: Aug. 17, 2021 | Health News

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By Ernie Mundell HealthDay Reporter (HealthDay) Here are some of HealthDay’s top stories for Tuesday, Aug. 17: Despite its proven effectiveness, too few hospitalized COVID patients get dexamethasone. Studies have shown that the steroid dexamethasone can help the sickest COVID-19 patients survive. So why are so many of these patients not getting it? Read more […]

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18Aug

Evolving Options for Newly Diagnosed Multiple Myeloma

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During a recent tweet chat with Alexander M. Lesokhin, MD, a hematologic oncologist with Memorial Sloan Kettering Cancer Center, joined Targeted Oncology to discuss the case of a 72-year-old White man with newly-diagnosed multiple myeloma. During the scenario, the man presented to his primary care physician complaining of fatigue. The patient has a medical history […]

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18Aug

Dexamethasone Can Help the Sickest COVID Patients Survive. So Why Are Too Few Getting It? | Health News

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By Alan Mozes HealthDay Reporter (HealthDay) TUESDAY, Aug. 17, 2021 (HealthDay News) — There’s strong evidence that the steroid drug dexamethasone can significantly lower hospitalized patients’ risk of dying from COVID-19, but many who might benefit from it the most aren’t getting it. “Dexamethasone is a steroid that is used for the treatment of arthritis, […]

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17Aug

Effects of Vitamin D and Dexamethasone on Lymphocyte Proportions and Their Associations With Serum Concentrations of 25-Hydroxyvitamin D(3) In Vitro in Patients With Multiple Sclerosis or Neuromyelitis Optica Spectrum Disorder

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This article was originally published here Front Immunol. 2021 Jul 29;12:677041. doi: 10.3389/fimmu.2021.677041. eCollection 2021. ABSTRACT BACKGROUND: Clear associations have been found between vitamin D deficiency and several autoimmune diseases including multiple sclerosis (MS). However, the benefits of vitamin D supplementation on disease management remain a matter of debate. OBJECTIVE AND METHODS: Patients with MS […]

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17Aug

Dexamethasone may be ‘underused’ among critically ill patients with COVID-19

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August 16, 2021 2 min read Source/Disclosures Disclosures: Healio Primary Care could not confirm relevant financial disclosures at the time of publication. ADD TOPIC TO EMAIL ALERTS Receive an email when new articles are posted on Please provide your email address to receive an email when […]

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15Aug

Corticosteroid switch from prednisone to dexamethasone in metastatic castration-resistant prostate cancer patients with biochemical progression on abiraterone acetate plus prednisone

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This article was originally published here BMC Cancer. 2021 Aug 13;21(1):919. doi: 10.1186/s12885-021-08670-2. ABSTRACT BACKGROUND: To assess the efficacies and potential predictors of a corticosteroid switch in metastatic castration-resistant prostate cancer (mCRPC) patients with biochemical progression on abiraterone acetate plus prednisone (A + P). METHODS: Patients with mCRPC treated between April 2016 and August 2020, […]

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