Idiopathic Pulmonary Fibrosis

Description – The Brand name of this medicine is Pirfisun. Pirfisun medicine contains generic Pirfenidone. Pirfenidone is available in form of Tablet. Each Coated Tablet contains 200Mg Pirfenidone. Manufacturer & Marketed company name of Pirfisun is Sunrise Remedies Pvt. Ltd. USED – Pirfisun Tablet is used in the treatment of idiopathic pulmonary fibrosis.  Dosage- As […]

KEGG DRUG: Nintedanib esylate     DRUG: Nintedanib esylate Help Entry D10396                      Drug                                    Name Nintedanib esylate (USAN);Nintedanib ethanesulfonate (JAN);Ofev (TN) Product Formula C31H33N5O4. C2H6O3S Exact mass 649.257 Mol weight 649.7571 Structure Mol fileKCF fileDB search Simcomp Neighbor Class Antineoplastic DG01918  Tyrosine kinase inhibitorMetabolizing enzyme substrate DG02924  UGT substrateTransporter substrate DG01665  ABCB1 substrate Remark Therapeutic category:  3999 Product (DG01374):  D10396<JP/US> Efficacy Antifibrosis, Tyrosine kinase […]

This report displays the potential drug interactions for the following 2 drugs: Esbriet (pirfenidone) Mekinist (trametinib) Edit list (add/remove drugs) Interactions between your drugs No interactions were found between Esbriet and Mekinist. However, this does not necessarily mean no interactions exist. Always consult your healthcare provider. Esbriet A total of 230 drugs are known to […]

Drug Details Pirfenidone is an antifibrotic and anti-inflammatory drug approved to treat IPF in the US, Europe, Canada, Asia, and Australia. In clinical trials, pirfenidone has been shown to slow progression of mild-to-moderate idiopathic pulmonary fibrosis. It is taken by mouth three times a day.  Study Purpose The purpose of this study is to to assess the […]

Cytokines are a group of secreted proteins that display diverse biological activity. They are especially important in the body’s response to injury. They subserve a variety of both autocrine and paracrine functions by activating numerous intracellular second-messenger signaling pathways. Cytokines are known to mediate many inflammatory processes, and the inappropriate presence of cytokines in the […]

Genes 8 proteins predicted to have the Interferon alpha/beta receptor, beta chain protein domain from the InterPro Predicted Protein Domain Annotations dataset. Symbol Name F3 coagulation factor III (thromboplastin, tissue factor) IFNAR1 interferon (alpha, beta and omega) receptor 1 IFNAR2 interferon (alpha, beta and omega) receptor 2 IFNGR2 interferon gamma receptor 2 (interferon gamma transducer […]

Clinical-stage biopharmaceutical company Faron Pharmaceuticals announced updated survival data from the phase 1 and 2 study investigating the safety and efficacy of ‘bexmarilimab’ on Wednesday. The AIM-traded firm said the updated results included the 30 patients from part one and the 110 patients from part two of the trial. For all of the patients, the […]

Objective: To analyze the efficacy and safety of nintedanib in patients with fibrosing autoimmune disease-related interstitial lung diseases (ILDs) with a progressive phenotype. Methods: The INBUILD trial enrolled subjects with a fibrosing ILD other than idiopathic pulmonary fibrosis, with diffuse fibrosing lung disease of >10% extent on high-resolution computed tomography, forced vital capacity (FVC) ≥45% […]

Författare Graham S Cooke Sarah J Campbell Jackson Sillah Per Gustafson Boubacar Bah Georgio Sirugo Steve Bennett Keith P W J McAdam Oumou Sow Christian Lienhardt Adrian V S Hill Summary, in English RATIONALE: Interferon-gamma (IFN-gamma) is of central interest in the study of tuberculosis. A number of single-gene mutations have been identified in the […]

Specifications HOST SPECIES: Mouse SPECIES REACTIVITY: Human IMMUNOGEN: The monoclonal antibody was produced in BALB/c x ICR F1 mice using recombinant IFN-gamma as the immunizing antigen. CONJUGATE: Unconjugated TESTED APPLICATIONS: E, WB APPLICATION NOTE: ELISA:In a sandwich ELISA (assuming 100 μL/well), a concentration of 4.0-8.0 μg/mL of this antibody will detect at least 500 pg/mL […]

High Sensitive ELISA Kit for Interferon Gamma (IFNg) Click here for more product information in PDF See REFERENCES here Intra-assay Precision (Precision within an assay): 3 samples with low, middle and high level High Sensitive Interferon Gamma (IFNg) were tested 20 times on one plate, respectively. Inter-assay Precision (Precision between assays): 3 samples […]

To investigate the effect of a group of novel synthetic dithiolane analogs of lignans and a well characterized platelet-activating factor (PAF) receptor antagonist, L659,989 on PAF-receptor binding, IFN-gamma- and lipopolysaccharide (LPS)-induced NO production, and steady-state inducible nitric-oxide synthase (iNOS) mRNA expression. PAF-receptor binding study was performed by displacement of 3H-PAF from rabbit platelet membrane; NO […]

15) What is the interferon-gamma release assay?a) The antigen detection test for theMycobacterium sppb) The DNA detection test inMycobacterium sppc) The test used as an alternative tuberculin skin test in latenttuberculosisd) The test used as an alternative tuberculin skin test in the activetuberculosis 16) The specimen of theMycobacterium tuberculosisshould be handledwith safety and caution, which […]

Interferon gamma-1b compared with placebo in metastatic renal-cell carcinoma. Canadian Urologic Oncology Group. N Engl J Med.  1998; 338(18):1265-71 (ISSN: 0028-4793) Gleave ME; Elhilali M; Fradet Y; Davis I; Venner P; Saad F; Klotz LH; Moore MJ; Paton V; Bajamonde A BACKGROUND: Most trials of immunomodulators in metastatic renal-cell carcinoma have been uncontrolled and subject to selection bias. The objective of this blinded, placebo-controlled study was […]

Comparison of tuberculin skin test and interferon-gamma release assay in the diagnosis of latent tuberculosis infection among Indonesian health-care workers – Fingerprint — Universitas Indonesia Sort by Weight Alphabetically Medicine & Life Sciences Interferon-gamma Release Tests 100% Latent Tuberculosis 88% Tuberculin Test 86% Skin Tests 69% Occupational Groups 48% Delivery of Health Care 41% Infections […]

ChemicalBook >  제품 카탈로그 Nintedanib impurity 26/(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester Nintedanib impurity 26/(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester 카스 번호:2102162-79-6 한글명:Nintedanib impurity 26/(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester 동의어(한글): 상품명:Nintedanib impurity 26/(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester 동의어(영문):(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester;Nintedanib impurity 26/(3Z)-2,3-Dihydro-2-oxo-3-(phenyl-1-piperidinylmethylene)-1H-indole-6-carboxylic acid methyl ester CBNumber:CB14902431 분자식: 포뮬러 무게:0 MOL 파일:Mol file […]

Catalog Number: USB-211413-BIOTIN Product Overview Article Name: IFI16 (Interferon gamma-inducible Protein 16, PYHIN2, IFNGIP1) (Biotin), IgG, Rabbit, Polyclonal Biozol Catalog Number: USB-211413-BIOTIN Supplier Catalog Number: 211413-Biotin Alternative Catalog Number: USB-211413-BIOTIN-100 Manufacturer: US Biological Host: Rabbit Category: Antikörper Application: IHC, IF, WB Species Reactivity: Human Immunogen: Recombinant protein corresponding to human IFI16. Product Description This gene […]

Pirfenidone in idiopathic pulmonary fibrosis. Eur Respir J.  2010; 35(4):821-9 (ISSN: 1399-3003) Taniguchi H; Ebina M; Kondoh Y; Ogura T; Azuma A; Suga M; Taguchi Y; Takahashi H; Nakata K; Sato A; Takeuchi M; Raghu G; Kudoh S; Nukiwa T;   Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without proven effective therapy. A multicentre, double-blind, placebo-controlled, randomised phase III clinical trial was conducted in Japanese patients with well-defined […]

Summary The recombinant outer membrane protein OprF/I has been demonstrated in previous studies to protect against Pseudomonas aeruginosa infection through a mechanism of enhanced antibody-mediated opsonophagocytosis. Recent evidence indicates that P. aeruginosa enhances its virulence phenotype as a consequence of binding to human IFN-gamma through an outer membrane protein, OprF. In this study, we demonstrate […]

Allergic immunity is orchestrated by group 2 innate lymphoid cells (ILC2s) and type 2 helper T (Th2) cells prominently arrayed at epithelial- and microbial-rich barriers. However, ILC2s and Th2 cells are also present in fibroblast-rich niches within the adventitial layer of larger vessels and similar boundary structures in sterile deep tissues, and it remains unclear […]