Why does FragGeneScan, a metagenome gene prediction tool, use a 6-periodic HMM?

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Hello, I would like to know why the metagenome gene prediction tool, FragGeneScan uses a 6-periodic HMM to represent the coding region.

Why did this tool choose a 6-cycle HMM instead of a 3-cycle HMM even though the codon is composed of 3 nucleotides?

I couldn't find this answer as far as I read the paper.

academic.oup.com/nar/article/38/20/e191/1317565

six-periodic hidden Markov model (HMM). (The figure below (i) and (vii) [Rho M, et al. 2010])

enter image description here

Thank you!


gene


prediction


Markov-model


metagenome

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