I have few human genome, it's paired end 151bp. I have 74 samples divided in 8 (4*2) fastq for each (592 files in total).
I want to know which aligner is the best ? It's seem difficult to choose...
I work on an hpc with this technical information:

Nodes 32
Physical cores 420
Maximum cores number per node 64
RAM 2,5 To
Maximum RAM per node 256Go
Graphical processors
GPU Node 1
GPU 4 (Tesla K80)
Cuda cores 19968
RAM 128 Go

Thanks a lot and sorry for this "general" question, it's the first time i do this...



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