What is the difference between Assignment and Prediction?

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I am absolutely new to Structural Bioinformatics (only started last week). I am working on the secondary structure assignment/prediction (actually I am not sure) of proteins using ML.

When it comes to protein analysis, most of the books or research papers talk about protein structure Prediction. Only a handful of books or articles talk about protein structure Assignments.

Can anyone tell me what is the basic difference between Assignment and Prediction?


protein


protein-structure


protein-structure-prediction

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Assignments are made from known 3D structures, and are fairly straightforward. Predictions are made without 3D structures. They are usually based on residue conservation profiles that are extracted from multiple sequence alignments.

Assignment of secondary structures to known secondary structures is a relatively simple bioinformatics task.

The definition of a prediction is a forecast or a prophecy. An example of a prediction is a psychic telling a couple they will have a child soon, before they know the woman is pregnant.


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