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3 hours ago by

I have 800 isolates of HCV virus isolation year range from 2004 to 2018, for that I am analysing Bayesian skyline plot. For some years I have 100 sequences and for some years I have only 10 sequences. Will II have to keep sample size for each year same or it may different. Will it create any sample size bias in BSP plot? Kindly guide me.

data looks like this; Can I use it?

2018(10 strains),
2017(51),
2016(45),
2015(175),
2014(89),
2013(18),
2012(49),
2011(70),
2010(88),
2009(200),
2008(6),
2007(9),
2006(13),
2004(5),



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