<br /> The Science Advisory Board <br />







Potential of gene editing for clinical use highlighted at ASGCT 2021

May 13, 2021 -- From base editing to in vivo CRISPR therapeutics and CRISPR-modified bacteriophages, scientists discussed innovations in preclinical research that have allowed them to advance these unique products to the clinic during a scientific symposium at the 2021 American Society of Gene & Cell Therapy (ASGCT) virtual meeting.
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Life science microscopy techniques get AI upgrade

May 11, 2021 -- Artificial intelligence (AI) can be used to speed up the computationally intensive process of light-field microscopy, a 3D microscopic imaging method. Researchers who developed the technique refer to it as hybrid LFM (HyLFM) and described the method in a paper published on May 7 in Nature Methods.
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Leveraging optofluidics to make therapeutic antibody discovery easier

May 10, 2021 -- The need for speed and accuracy in the development of therapeutic antibodies has prompted Berkeley Lights to upgrade its optofluidic tools to help customers improve the quality of their therapeutic antibody products. John Proctor, PhD, senior vice president of antibody therapeutics at Berkeley Lights, spoke with ScienceBoard.net about some technological advancements the company has recently launched.
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Preparation is key for postdocs to transition to industry positions

May 7, 2021 -- Postdoctoral positions are a natural choice for many scientists who have just received their PhDs. Postdocs allow scientists to gain invaluable research experience and training under guided mentorship -- and potentially transition to industry jobs, explains Natalia Martin, PhD, a program manager at the American Chemical Society.
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Hope for next-gen COVID-19 vaccines may rest in an unexpected region of the virus

May 5, 2021 -- Researchers further elucidated how antibodies produced in people who effectively fight off SARS-CoV-2 work to neutralize the part of the virus responsible for causing infection. The study, published in Science on May 4, describes how antibodies targeting sections of the virus outside of the receptor-binding domain may be useful in the development of vaccines and therapies.
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Single-cell atlas of human teeth exposes root of stem cell behavior

May 3, 2021 -- The first comprehensive single-cell atlas of the human tooth reveals how different dental tissues control the activity of stem cells. Published recently in iScience, the study used advanced single-cell sequencing technology to show that changes in the cellular environment may explain differences in the behavior of stem cells.
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How the South African SARS-CoV-2 variant evades antibodies

April 29, 2021 -- Computer modeling has demonstrated that one of the three mutations of the South African SARS-CoV-2 variant reduces its ability to bind to human cells. The results, published recently in the Journal of Medicinal Chemistry, also suggest that the mutation may help it escape some therapeutic antibodies.
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Nanoparticles may offer new way to tackle antibiotic-resistant bacteria

April 26, 2021 -- A team of researchers has developed nanoparticles that use a completely different mode of action from conventional antibiotics. These inorganic nanoparticles have inherent antimicrobial properties and can target pesky bacteria that hide inside of cells. The results were published in Nanoscale on April 22.
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Naturally occurring molecule helps SARS-CoV-2 evade neutralizing antibodies

April 23, 2021 -- Researchers have identified naturally occurring molecules that are created from the breakdown of hemoglobin and block the binding of a subset of human antibodies to SARS-CoV-2. The discovery, published in Science Advances on April 22, may help explain why some COVID-19 patients can become severely ill despite having high levels of antibodies against the virus.
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