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2 hours ago by

Brazil

Hi everyone. I'm studying two SNPs in a case/control study and one part of the analysis is to test for additive model. So the question is: Can I use logistic regression for this task or should I just build a 2x2 table and perform Fisher exact test?
The data looks like this:

Outcome SNP_1 SNP_2 Gender Age
1       AA    GG    M      45
0       AC    GT    F      54
1       CC    TT    F      65

Outcome = 0 (Control); 1 (Case)

SNP_1: A = Risk

SNP_2: T = Risk

For logistic Regression, how can I format my data to fit in this kind of model? Should I just convert my genotypes to 0, 1, 2, merge both SNPs into a single column and use Outcome ~ SNP, family = binomial or there's another way to do this?

Thanks.

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brunobsouzaa240



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