Hi everyone. I'm studying two SNPs in a case/control study and one part of the analysis is to test for additive model. So the question is: Can I use logistic regression for this task or should I just build a 2x2 table and perform Fisher exact test?
The data looks like this:
Outcome SNP_1 SNP_2 Gender Age 1 AA GG M 45 0 AC GT F 54 1 CC TT F 65
Outcome = 0 (Control); 1 (Case)
SNP_1: A = Risk
SNP_2: T = Risk
For logistic Regression, how can I format my data to fit in this kind of model? Should I just convert my genotypes to 0, 1, 2, merge both SNPs into a single column and use
Outcome ~ SNP, family = binomial or there's another way to do this?