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2 hours ago by

Greece

Dear All,

I would like to ask if there is a pathogenicity or deleteriousness score implemented in any tool, regarding the process of somatic variant annotation, that could be used specifically in the case of putative somatic insertions/deletions, derived from the analysis of WGS/WES cancer data ? And could be utilized in the sense of prioritization, but solely for INDELs ?

Based on an initial searching, I took a look for the CADD score included in the ANNOVAR database, but unfortunately is underlined that is primarily used for SNPs (doc-openbio.readthedocs.io/projects/annovar/en/latest/user-guide/filter/#cadd-annotations)

Any idea or suggestion from any experienced user would be grateful !!

Kind Regards,

Efstathios-Iason



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