Reactome physical association pairs in the human protein-protein interactions data

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I am using the data at the "Human protein-protein interactions" link on the Reactome web page. Here is the link to the actual data. My first question is: is this data representing directed interactions? And here is a second, a followup question. I realized there are cases where both A<physical association>B and B<physical association>A pairs exist in this data, where A and B are two proteins and physical association is the Interaction type. Does this mean both directions of interactions exist, i.e. A acts on B and B acts on A?


reactome


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ppi

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