Research Associate in Computational Biophysics, University of Manchester

Job reference: BMH-017047

Location: Oxford Road, Manchester, UK Closing date: 19/08/2021 Salary: £32,816 per annum Employment type: Fixed Term Faculty/Organisation: Biology, Medicine & Health School/ Directorate: Molecular & Cellular Function Hours per week: Full Time Contract Duration: 01 August 2021 until 31 July 2024

This is a Postdoctoral Research Associate opportunity to take part in the BBSRC funded project: Prospecting for pH-sensors in host and pathogen systems. This post, based at The Manchester Institute of Biotechnology at The University of Manchester, UK, is available from 1st August for 3 years.

You will participate in a challenging and exciting project to develop models for understanding pH-dependence in biology. The focus of this position is computational, but with biophysical collaboration for testing predictions programmed into the work plan. Algorithms to predict pH-dependent effects have been developed, but their application to biological systems has been largely piecemeal, studying individual elements. This project seeks to apply prediction methods to detect pH-sensing across a range of biological processes, including virus infection and adaptation to altered pH in cancer, informed where possible by high throughput datasets. Specific systems and pH-sensors will be tested in a biophysics collaboration, thus benchmarking the model. Our aim is develop a broadly applicable model for discovering pH-sensors, to make it available through web tools, and to encourage usage across biological fields, recognising the widespread evolution of pH-dependent mechanisms in intracellular and extracellular environments. The overall philosophy for developing and presenting methods follows that used for existing tools available at our website, www.protein-sol.manchester.ac.uk.

This project is a collaboration between 3 groups at the University of Manchester, Dr Jim Warwicker (algorithm development), Professor Perdita Barran (biophysical testing of pH-sensors), and Dr Siddharth Banka (genetics).

The School is strongly committed to promoting equality and diversity, including the Athena SWAN charter for gender equality in higher education. The School holds a Silver Award which recognises their good practice in relation to gender; including flexible working arrangements, family-friendly policies, and support to allow staff achieve a good work-life balance.

Enquiries about the vacancy, shortlisting and interviews: Name: Dr Jim Warwicker, Email: [email protected].

General enquiries: Email: [email protected]

This vacancy will close for applications at midnight on the closing date.

Please see this link for the Further Particulars document which contains the person specification criteria. further particulars

Apply for the job here: apply



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