Negative values in Cox regression analysis

1

Hi there.
I am working on gene expression data of a pan-cancer project. I am new in survival analysis and have a question about coxph function in R package "survival". I have z-score of my gene expression levels which contains negative and positive values.
the question is ,can I use this data with negative values to perform univariate cox regression analysis?
what about multivariate cox regression analysis?
Thanks.


survival


CoxPH


coxregression

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