gravatar for loic.mangnier.1

4 hours ago by

Hello there,

I currently work on regulatory network building based on Hi-C and I would like to validate them with a co-expression based approach.
Briefly, I have clusters with several enhancers and promoters which are linked each other (the cluster size is moderate, between 2 and 20 elements in average) and I would like to show similar patterns in expression for the genes of the same cluster.
I looked at the co-expression through expression correlation for different replicates, but I am not sure to integrate this to my existing networks.
I wonder if simple methods could be used to illuminate the expression behaviour of my genes in the same cluster without proceed to resampling methods.

Any insights are welcome.

Thank you,

Loic



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