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2 hours ago by

Hello,

There is a big and increasing number of methods used for between sample normalization in whole genome metagenomics and yet no consensus which to apply Normalization Methods. Rarefaction is not a very suitable choice IMHO.

Do you have experience with that? If sequencing depth does not vary greatly (lets say at most factor 3), would it be an option to just not apply normalization at all?

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plicht0



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