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3 hours ago by

My lecture notes in Bioinformatics try to explain how to work out position specific scoring matrix, or position weight matrix. They use the following example in the notes. I understand the formula but I don't see how they could calculate -2.94 for a frequency/base count of 0, as log2(0) isn't a number. Could somebody explain how they might have found -2.94 for the 0 base counts? I am also not sure what pb value they used. I assume fbi means the base count (frequency)
Image here of their explanation

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jbrody110



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