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2 hours ago by


I have RNA seq Data (n=15) paired with antibody response data(n=15) at day 10. The question that I want to ask is that which genes sets/pathways get most pertuebed at day 10 in repose to vaccination. I get my spearman correlation values between each genes and antibody response at day 10. I wanted to do preranked GSEA with correlation values but the thing is that correlation values for a lot go genes come same which I could expect because there are many genes that should be coexpressed and does not change their expression generally and in response to antibody we expect say couple o 100 genes changes at day 10. so what can be my option because preranked Gsea do not resolve ties. Additionall I have both responders and not responders in my data.


modified 2 hours ago

2 hours ago


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