Hi, I think that the function documentation explains it quite well, and in a simple way.

Key points:

  1. The inverse hyperbolic sine ('arcsinh') transformation is widely
    used in cytometry
  2. arcsinh is similar to log transformation at high values, but is
    'linear' with values near zero. So, unlike log, arcsinh can work with zero values, and even small negative values
  3. This arcsinh transformation comes with one key adjustable parameter:
    'cofactor'
  4. Cofactor controls the 'width' of this linear region
  5. Recommended values for cofactor are 5 for mass cytometry and CyTOF,
    or 150 for flow cytometry

Kevin


Login
before adding your answer.

Traffic: 1800 users visited in the last hour



Source link