fixed effect vs random effects RNA analysis

1

Hi, when choosing a formula for the differential expression analysis in R, for e.g. to RNA count data, how do i choose exactly in which variable put the (1|x), i.e. when a variable must be modeled as random or fixed effect ? The decision is only based if the variable is continuous or categorical?

what are the differences between ~ feature + AGE + (1|SEX) + (1|GROUP) + (1|Individual) and ~ feature + AGE + SEX + GROUP + (1|Individual)

where group is the category of a subject and individual is just the ID used for dealing with repeated measures.


variancePartition


voom


LIMMA


DE


RNA

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