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2 hours ago by

Ulm

As I've understood Seurat properly, in the initial steps, it performs scaling and centering of the data so that your data resembles a normal distribution using the ScaleData() function. If this is the case, then why does the default test for differential expression have the Wilcoxon test when it is a non-parametric test? would it not be better off to use DESeq2 instead and trust the results from DESeq2?

Please do correct me if i'm going wrong in my understanding anywhere here.

Thank you.
Suvi



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