I have downloaded both the tsv file and bigwig file for CADD scores. However, upon inspection these two files contain different information. For example a tsv file has following content:
#Chrom Pos Ref Alt RawScore PHRED 1 10001 T A 0.702541 8.478 1 10001 T C 0.750954 8.921 1 10001 T G 0.719549 8.634 1 10002 A C 0.713993 8.583
So for each position there is an alternate variant and for each alternate variant there is a CADD score.
However, I read bigwig file using python library bigwig and when I use intervals to get the correspond CADD score, I get only one score instead of three like in tsv
bw = pyBigWig.open("CADD_GRCh38-v1.6.bw") bw.intervals('chr1',10001,10002)
The result I get is the following:
((10001, 10002, 8.854000091552734),)
Which variant does this score belong to? And how can I get a score for each of the alternate variant using bigWigFile.