Cell Bank Research Associate II, Analytical DevelopmentPosition SummaryWe are seeking a Research Associate II to join an exciting, fast-growing and well-financed company to develop novel gene editing therapies for serious diseases. The successful candidate will join the Technical Operations (Tech Ops) group at CRISPR Therapeutics, focusing on the development of primary cell banks to support gene editing programs. The individual will be responsible for isolating primary cells from donor samples, developing quantitative assays for measuring consistency across donors, and screening donors to ensure reproducibility across cell-based assay runs. The successful candidate will independently design, perform, and analyze experiments for multiple preclinical and clinical programs, and will work independently to support process development and product characterization.

Responsibilities

  • Develop and maintain T-cell banks used for cell-based potency assays
  • Develop and maintain CD34+ stem cell banks for supporting process characterization
  • Develop and qualify quantitative assays used to measure consistency across donor samples
  • Work with Process Development to generate and analyze process development data to develop an understanding of cellular product critical product parameters to guide testing and process control strategies
  • Develop data sets supporting product specification and for qualification and/or validation of cell-based assays at CMOs and GMP test labs
  • Author technical reports on assay development/optimization, qualification and test method SOPs
  • Analyze and present experimental data
  • Assess and implement new analytical technologies

Minimum Qualifications

  • BS in life sciences and 2+ years of relevant assay development experience in industry or an MS.
  • Experience with cell culture and flow cytometry is required
  • Hands-on experience in development of cell banks is desired
  • Experience working with primary cells is desired
  • Excellent oral and written communication skills

Preferred Qualifications

  • Experience using automated cell processing systems such as the CliniMACs Prodigy
  • Understanding of analytical method development, qualification/validation
  • Knowledge of relevant guidance on analytical development and validation (USP, ICH, FDA, EMA)
  • Experience with assay development for immunology or immuno-oncology products
  • Experience in assay development for cell and gene therapy products
  • Experience in development of cell-based potency assays
  • Experience in tech transfer of assays to QC labs

Competencies

  • Collaborative – Openness, One Team
  • Undaunted – Fearless, Can-do attitude
  • Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
  • Entrepreneurial Spirit – Proactive. Ownership mindset.

If interested and qualified, please include Requisition # 2018-401 in the subject line when emailing resume to: [email protected].

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

To view our Privacy Statement, please click the following link: www.crisprtx.com/about-us/privacy-policy



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