Contradiction in Harzard ratio and Log fold change
Hi there. I am working on a pan-cancer project that contains 12 cancers. The data in use is TCGA RNA-seq data. I have found 37 genes that are involved in survival of patients.I performed a Differential expression between normal and cancer patients. then I have performed a CoxPH model between Dead and Alive Cancer patients on selected genes. dead = 1 and survive= 0.
I calculated LogFC of each gene expression between cancer and normal.
I know that genes with Posetive LogFC and +1 HR are known as bad prognostic. also genes with negative LogFC and 0<HR<1 are known as good prognostic.
but my Problem is, that some genes contain negative Log FC and +1 HR or posetive LogFC wirh HR value less than 1.
what does it mean? Thanks
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