Cellular deconvolution intuition
Cellular deconvolution yields the proportion of cell types from bulk tissue.
After estimating the proportion of each cell type, why cannot one multiply the total expression by the proportion to get the expression by cell type?
Unsupervised (reference free) deconvolution yields the proportion without relying on a reference profile. How this is possible?
Could you provide a simple intuition to think about deconvolution that could explain these?
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