Genetics

A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose immunization regimen. A similar vaccine candidate was previously shown to be safe and tolerable with a three-dose intramuscular injection […]

Here’s one ‘on the house’, in part copied from 2 previous answers that I have given on this topic: rankedGenes <- c(1:20) names(rankedGenes) <- c(“BRCA1″,”BRCA2″,”TP53”, “ATM”, “ERCC1”, “BRCC3”, “TP63”, “ERCC2”, “ERCC3”, “ERCC4”, “TP63”, “S100A2”, “CXCL2”, “CXCL3”, “MS4A1”, “MS4A2”, “VCAM1”, “VSX1”, “CD8”, “S100A2”) rankedGenes BRCA1 BRCA2 TP53 ATM ERCC1 BRCC3 TP63 ERCC2 ERCC3 ERCC4 TP63 1 […]

Low-dose Administration of MERS DNA Vaccine Candidate Induces Potent Immunity and Protects From Virus Challenge in Preclinical Models PHILADELPHIA — (April 22, 2021) — A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when […]

Advances lately in the genome-editing space include Beam Therapeutics Inc. publication in The CRISPR Journal details of its work with inlaid base editors, which the firm is applying in the BEAM-102 program for sickle cell disease. IBEs’ predictable, shifted editing window lets researchers go after disease-causing mutations that canonical base editors cannot reach, Beam said, […]

How to extract this information 0 Hi there, I am a beginner in bioinformatics and I would like the following information but do not know how to manipulate cufflinks gtf files (produced in galaxy) to in order to get it…. I would like gene_id, gene_name, chromosome number and start position of the gene and then […]

Read Article Efforts are being ramped up for massive production of COVID-19 vaccines and make them available in the shortest possible time, said Renu Swarup, Secretary, Department of Biotechnology, stressing that India currently has a promising pipeline of four-five vaccine candidates, while three have already been approved for emergency use. She said financial support of […]

Differentially expression analysis 3 Heyya, I’m performing a DE analysis on 5 groups, 1 control and 4 mutants. The pipeline so far went: Raw data –> Trimmomatic –> Bowtie2 –> FeatureCounts –> Limma-Voom. I got the Limma-Voom report with the graphs and the 4 contrasts I set up: Control-Mutant1, Control-Mutant2, Control-Mutant3, Control-Mutant4. Everything is great, […]

(Photograph by Joel Sagat/AFP/Getty Images.) An article from The Defender, a news website that describes itself as “an online news site to evade official censorship, to report fact-based news and sponsor the kind of honest debate that terrifies the new generation of corporate and government commissars,” claims that scientific research suggests that coronavirus mRNA vaccines […]

Vertex Pharmaceuticals Incorporated (NASDAQ:VRTX) went down by -0.18% from its latest closing price compared to the recent 1-year high of $306.08. The company’s stock price has collected 1.21% of gains in the last five trading sessions. Barron’s reported 16 hours ago that Crispr Therapeutics Is Upgraded After $900 Million Deal Get the hottest stocks to […]

Differentially expression analysis 1 Heyya, I’m performing a DE analysis on 5 groups, 1 control and 4 mutants. The pipeline so far went: Raw data –> Trimmomatic –> Bowtie2 –> FeatureCounts –> Limma-Voom. I got the Limma-Voom report with the graphs and the 4 contrasts I set up: Control-Mutant1, Control-Mutant2, Control-Mutant3, Control-Mutant4. Everything is great, […]

IMAGE: Wistar Drs. David Weiner and Ami Patel view more  Credit: The Wistar Institute PHILADELPHIA — (April 22, 2021) — A synthetic DNA vaccine candidate for Middle East respiratory syndrome coronavirus (MERS-CoV) developed at The Wistar Institute induced potent immune responses and afforded protective efficacy in non-human primate (NHP) models when given intradermally in abbreviated, low-dose […]

Our indicative theme of Gene Editing stocks is down by about 18% year-to-date, compared to the S&P 500 which is up by about 11% over the same period. The underperformance comes as declining Covid-19 cases and higher vaccination rates in the U.S. have made investors move from highly valued growth and speculative stocks to more […]

CRISPR Therapeutics AG (NASDAQ:CRSP) – Investment analysts at Oppenheimer issued their Q1 2021 earnings estimates for CRISPR Therapeutics in a report released on Wednesday, April 21st. Oppenheimer analyst J. Olson forecasts that the company will post earnings of ($1.37) per share for the quarter. Oppenheimer currently has a “Outperform” rating and a $187.00 target price […]

Companies in the Healthcare sector have received a lot of coverage today as analysts weigh in on Intuitive Surgical (ISRG), Crispr Therapeutics AG (CRSP) and Edwards Lifesciences (EW). Intuitive Surgical (ISRG) In a report released today, Drew Ranieri from Morgan Stanley maintained a Hold rating on Intuitive Surgical, with a price target of $855.00. The […]

You could use the BEDOPS kit to solve this. $ awk -v FS=”t” -v OFS=”t” ‘{ n=split($2, a, “:”); print a[1], a[2]-1, a[2]; }’ original_table.txt | sort-bed – > positions.bed Get annotations: $ wget -qO- hgdownload.cse.ucsc.edu/goldenpath/hg38/database/refGene.txt.gz | gunzip -c – | awk -v FS=”t” -v OFS=”t” ‘{ if (!match($13, /.*-[0-9]+/)) { print $3, $5, $6, […]