Electroporation has been described as a method of inducing an increase in the cell membrane’s permeability with the application of an electric field. This method has allowed lead molecules of interest as chemotherapeutics into the target cells. Two types of electrodes have been used for electroporation: penetrating and nonpenetrating with a plate.
Some electroporation-based treatments include electrochemotherapy, gene electrotransfer, and their combinations. They have been reported to be safe, fast, and effective. However, they have been mostly recommended for the treatment of solid tumors for clients that have declined surgery or radiotherapy.
Data have been shown that electroporation-based treatments are cost-effective for oral tumors such as small squamous cell carcinoma and malignant melanoma tumors that do not involve the bone. These patients have reported a good response to the treatment and higher survival time as well.
Besides all the clinical evidence collected, more investigation is required to improve treatment protocols, clinical reports, and to better interpret the mechanism of the electroporation-based treatments.
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