Choi M.J. · Maibach H.I.




Author affiliations

Department of Dermatology, University of California School of Medicine, SanFrancisco,Calif., USA




















Skin Pharmacol Appl Skin Physiol 2003;16:271–282

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Article / Publication Details


Received: March 24, 2002
Accepted: April 25, 2003
Published online: August 14, 2003

Issue release date: September – October


Number of Print Pages: 12

Number of Figures: 0

Number of Tables: 5


ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)


For additional information: www.karger.com/SPP

Abstract

Topical DNA vaccines have been shown to elicit both broad humoral and cellular immune responses in vivo. The skin is an attractive site for the delivery of DNA antigens for DNA vaccination. However, due to skin’s barrier properties, the penetration of DNA and the applications of topical vaccination are limited. To improve permeability, chemical and physical approaches have been examined to decrease stratum corneum barrier properties. Topical vaccination has been achieved using topical application of naked DNA, DNA/liposomes or emulsion complex, liposomal cream, as well as physical methods such as stripping, electroporation, and micromechanical disruption methods. All methods resulted in a significant enhancement in humoral and cellular immune responses over naked DNA alone. To develop more cost-effective and needle-free vaccines, skin-targeted immunizations are required. This review focuses on the chemical and physical methods developed to enhance DNA delivery into skin.

© 2003 S. Karger AG, Basel


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Article / Publication Details


Received: March 24, 2002
Accepted: April 25, 2003
Published online: August 14, 2003

Issue release date: September – October


Number of Print Pages: 12

Number of Figures: 0

Number of Tables: 5


ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)


For additional information: www.karger.com/SPP


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