<br /> The Science Advisory Board <br />

New method reclaims resolution of single-cell RNA-seq

October 14, 2020 -- A new approach to RNA sequencing can enable scientists to extract 10 times more information from a single cell, including gene expression and subtle differences between healthy and diseased cells. The study, published in Immunity on October 13, reveals the power of the improved Seq-Well method and provides evidence of its efficacy in five inflammatory skin diseases.
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EpiMorgify algorithm predicts best conditions for cell therapies

October 13, 2020 -- In order to determine optimal cell growth conditions for the development of cellular therapies, researchers have devised an algorithm called EpiMorgify that can predict what factors are needed to produce high-quality cultures. The study was published on October 9 in Cell Systems.
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Long-lasting IgG antibodies found in blood and saliva of COVID-19 patients

October 9, 2020 -- Researchers have discovered that immunoglobulin G (IgG) antibodies to the SARS-CoV-2 virus are longer lasting in the blood and saliva of COVID-19 patients compared to the relatively short-lived IgM and IgA responses. The finding, presented in a pair of studies published in Science Immunology on October 8, suggests that IgG antibodies could be a promising target to detect and evaluate immune responses to the virus.
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Will mutation of the SARS-CoV-2 virus affect vaccine effectiveness?

October 8, 2020 -- What impact will mutation of the SARS-CoV-2 virus have on the effectiveness of COVID-19 vaccines that are in development? In a new study published in NPJ Vaccines on October 8, Australian researchers say they believe that a recent change in the genetic material of the virus shouldn't reduce the effectiveness of vaccines coming to market.
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Novel nanoparticles deliver genetic therapy to bone marrow

October 6, 2020 -- Specialized nanoparticles can be used to deliver small interfering RNA to the bone marrow where they can turn off specific genes in bone-marrow endothelial cells to help treat heart disease or boost stem cell production, according to new research published in Nature Biomedical Research on October 5.
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Many mammals may be at high risk of SARS-CoV-2 infection

October 5, 2020 -- Despite broad interest in determining the origin of SARS-CoV-2 in the early days of the COVID-19 pandemic, the existence of an intermediate host between the source of the virus in bats and humans remains unknown. A study published in Scientific Reports on October 5 provides evidence that 26 species of mammals that are regularly in contact with humans may be susceptible to infection.
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Flood of COVID-19 papers allows substandard research to slip through

October 2, 2020 -- This year's deluge of COVID-19 research publications has allowed substandard research to be published by academic journals or to be housed on preprint servers, resulting in the retraction of some papers. The chaotic publishing environment has potentially harmful implications for COVID-19 patients during treatment, a leading bioethicist wrote in a brief published in the Journal of Medical Ethics on October 1.
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