Cell Transfection Platform

Figure 1

Lonza has launched the next generation of its popular Nucleofector Platform, the 4D-Nucleofector. Electroporation, the method by which DNA, RNA, or protein is introduced into cells through an electrical pulse to change their genotype or phenotype, is an important tool with a range of applications in disease research and drug discovery as well as in the advancement of gene therapies, immunotherapies, and stem cell generation. The 4D-Nucleofector Core Unit can operate up to three functional modules, allowing for tailored experimental setups, and can facilitate scale-up from low- to high-volume transfection. The Nucleofector family of units is now joined by a fully integrated 96-well unit to suit users with midscale transfection requirements for up to 96 samples at once. In addition, the updated Core Unit features an 8-in. touchscreen display, enabling users to easily set up their experiments and control all functional modules via the system's intuitive, user-friendly software. Further, optimized protocols are available for more than 750 different cell types and are designed to provide robust transfection conditions, leading to optimal results every time.

Flow Cytometry Dyes

Bio-Rad Laboratories introduces three StarBright Dyes designed for flow cytometry applications. StarBright Violet 570, 670, and 710 Dyes offer improved brightness and precise excitation and emission spectra, making them suitable for use in multicolor flow cytometry panels. Bio-Rad's line of StarBright Dyes offers researchers a range of fluorescent nanoparticles conjugated to highly validated flow antibodies. These dyes are compatible with new and existing protocols, suitable for use in multiplex panels, resistant to photobleaching, and highly stable with minimal lot-to-lot variation. StarBright Dyes are compatible with Bio-Rad's ZE5 Cell Analyzer, S3e Cell Sorter, and other conventional and spectral flow cytometers.

Adeno-Associated Virus (AAV) Reference Materials

AMS Biotechnology (AMSBIO) announces a new range of AAV reference materials of full capsids and empty capsids of six different serotypes. Enabling meaningful comparisons between gene therapy research studies and clinical trials, these well-characterized reference standards are extensively quality-analyzed with molecular based assays and transmission electron microscopy. AMSBIO's AAV reference materials (full capsids) with accurate vector genome concentration can be used in quantitative PCR–based vector genome quantification; additionally, they are well characterized for full-to-empty capsid ratio. AAV reference materials are available in AAV1, AAV2, AAV5, AAV6, AAV8, and AAV9 serotypes. AAVs are also known to produce empty particles without payloads. AMSBIO's high-purity, quality-certified AAV empty capsids reference materials can be used as controls and standards in assays, including HPLC and ELISA, and are offered in AAV1, AAV2, AAV5, AAV6, AAV8, and AAV9 serotypes.

Ghost Red Blood Cells

Rockland has developed new ghost red blood cells (RBCs) from a variety of hosts, including bovine, goat, rabbit, and sheep. Using proprietary methods unique to the host species, Rockland scientists can remove over 99% of hemoglobin from a pool of erythrocytes, leaving the membrane intact. Our ghost RBCs are (1) made to order; (2) characterized [i.e., Hb removal %, cell counts (optional)]; (3) shipped international and domestic; and (4) ready in as little as 1 week. RBCs are naturally designed carriers for drug delivery in the vascular system and present a safer approach for delivering encapsulated drugs because of their unique features, such as longer lifespan in the bloodstream and biocompatibility. Rockland's ghost erythrocytes can be used to remove unwanted molecules from the bloodstream, slow the release of drugs into the body, deliver antiviral molecules, study hemolysis, serve as antibody targets, and more.

Reactor Modules for Flow Chemistry

Uniqsis makes flow chemistry accessible to everyone through an expanding suite of affordable "plug and play" reactor modules. With its clear, bright LED display and simple "push-to-set" controller, the HotCoil is ideally suited for stand-alone operation. Alternatively, it can be controlled directly by the Uniqsis FlowSyn integrated flow chemistry system or the Binary Pump Module, or by using FlowControl system control software. The HotCoil is also compatible with a range of glass and stainless-steel column reactor/accessories to support various catalyst/enzymatic screening applications. HotChip is a stand-alone heater module that provides precise temperature control of flow chemistry glass static mixer (GSM) chip reactors. Available in sizes from 270 µL to 20 mL, GSM chips from Uniqsis can be used to perform reactions from −80°C to over 230°C. Used in conjunction with an external thermoregulation circulator, the Cold Coil II maintains stable temperatures between −78°C and 150°C for extended periods of time. The Cold Coil II is compatible with all Uniqsis coil reactors, from 2.0-mL up to 60-mL capacity.

Freeze Dryer

SP Scientific Products (SP) announces the launch of its SP Hull LyoStar 4.0 R&D and process-development freeze dryer, which enhances speed to market of biopharmaceutical products, such as biological drugs. Based on a full-scale production freeze dryer to support rapid scale-up, LyoStar 4.0 is a pilot-scale lyophilizer offering superior shelf mapping, rapid shelf freezing, unmatched process accuracy, and reliability. It also includes a cutting-edge suite of process analytical technology (PAT) tools, augmenting SP's Line of Sight technology suite. In addition, SP's new freeze dryer uses an "ecofriendlier" refrigerant gas, which reduces the carbon footprint involved in lyophilization. Lyophilization (freeze-drying) is a key step in the production of biologics, vaccines, and diagnostics, as it stabilizes sensitive biological products to extend their shelf life while maintaining their quality and efficacy. Over 40% of biopharmaceutical products are now freeze-dried for storage and transport, and this number continues to grow with the development of more complex drugs.

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