Irreversible electroporation (IRE) uses non thermoelectric pulse to ablate tumours, which is an effective cancer treatment method. The pulse is transmitted through a minimally invasive needle electrode inserted into the target tissue and causes cell death by creating nanoscale membrane defects. Irreversible electroporation has been shown to be safe and effective in the treatment of tumours of the brain, liver, kidney, pancreas and prostate located near key blood vessels and nerves. Determining the parameters accurately of the applied pulsed electric field to kill all tumour cells and minimize damage to healthy tissue is the key to the success of IRE for the treatment of malignant tumours. In this paper, according to the researches of irreversible electroporation in the treatment of tumour in recent years, the distribution of electric field and temperature in tissue during IRE is calculated by numerical method, which provides a methodological basis for the treatment of tumour ablation with IRE.



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