title={In vivo electroporation of the central nervous system: A non-viral approach for targeted gene delivery},
  author={J. D. Vry and P. Martinez-Martinez and M. Losen and Y. Temel and J. Prickaerts},
  journal={Progress in Neurobiology},
Electroporation is a widely used technique for enhancing the efficiency of DNA delivery into cells. Application of electric pulses after local injection of DNA temporarily opens cell membranes and facilitates DNA uptake. Delivery of plasmid DNA by electroporation to alter gene expression in tissue has also been explored in vivo. This approach may constitute an alternative to viral gene transfer, or to transgenic or knock-out animals. Among the most frequently electroporated target tissues are… Expand

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