Summary
In this phase II study we investigate the effect of calcium electroporation on cancer in the
skin investigated by histopathology.
Description
In this non randomized phase II study, we will explore histopathological tumour cell death
mechanisms in 12 patients with breast cancer metastases and 12 patients with other cutaneous
or subcutaneous malignancy. The primary endpoint of the biopsy study is to evaluate
differences in tumour infiltrating lymphocyte (TIL) population in tissue samples from treated
cancer tumours two days after calcium electroporation treatment compared to samples taken on
the day of treatment before the calcium electroporation procedure. TIL content in biopsies
will be evaluated by pathological examination and specified in percent of cells. Patients
will be followed up to 3 months and depending on number of treated tumors, biopsies will be
taken at different timepoints after one or two treatments with calcium electroporation. Other
analyses will include differences regarding tumour type, immune marker expression levels over
time, vascular effects and regressive changes as well as examining changes in systemic
immunological markers.
Study Design
Conditions
Cancer
Intervention
Calcium electroporation
Status
Not yet recruiting
Source
Zealand University Hospital
Results (where available)
Links
Published on BioPortfolio: 2020-02-07T16:09:07-0500
Medical and Biotech [MESH] Definitions
Calcium Signaling
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Intracellular Calcium-sensing Proteins
Intracellular signaling peptides and proteins that bind to CALCIUM. They undergo allosteric changes when bound to CALCIUM that affects their interaction with other signal-transducing molecules. They differ from CALCIUM-SENSING RECEPTORS which sense extracellular calcium levels.
Seer Program
A cancer registry mandated under the National Cancer Act of 1971 to operate and maintain a population-based cancer reporting system, reporting periodically estimates of cancer incidence and mortality in the United States. The Surveillance, Epidemiology, and End Results (SEER) Program is a continuing project of the National Cancer Institute of the National Institutes of Health. Among its goals, in addition to assembling and reporting cancer statistics, are the monitoring of annual cancer incident trends and the promoting of studies designed to identify factors amenable to cancer control interventions. (From National Cancer Institute, NIH Publication No. 91-3074, October 1990)
Receptors, Calcium-sensing
A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. They differ from INTRACELLULAR CALCIUM-SENSING PROTEINS which sense intracellular calcium levels.
Stromal Interaction Molecule 1
A stromal interaction molecule that functions in the regulation of calcium influx following depletion of intracellular calcium in the ENDOPLASMIC RETICULUM. It translocates to the plasma membrane upon calcium depletion where it activates the CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL ORAI1.
