Elsevier

Available online 2 August 2020, 105682

Computer Methods and Programs in Biomedicine

Highlights

A web platform for 3D simulation of the electric field distribution for electroporation-based therapies.

It illustrates the dependencies of the electric field distribution on electrodes’ positioning, orientation and length, on the applied voltage, and on the electric conductivity of the treated tissues.

A medical image can be loaded to place the electrodes according to anatomical landmarks. Thus, the simulated electric field is overlaid on the image.

Abstract

Background and objectives

Electroporation is the phenomenon by which cell membrane permeability to ions and macromolecules is increased when the cell is briefly exposed to high electric fields. In electroporation-based treatments, such exposure is typically performed by delivering high voltage pulses across needle electrodes in tissue. For a given tissue and pulsing protocol, an electric field magnitude threshold exists that must be overreached for treatment efficacy. However, it is hard to preoperatively infer the treatment volume because the electric field distribution intricately depends on the electrodes’ positioning and length, the applied voltage, and the electric conductivity of the treated tissues. For illustrating such dependencies, we have created EView (eview.upf.edu), a web platform that estimates the electric field distribution for arbitrary needle electrode locations and orientations and overlays it on 3D medical images.

Methods

A client-server approach has been implemented to let the user set the electrode configuration easily on the web browser, whereas the simulation is computed on a dedicated server. By means of the finite element method, the electric field is solved in a 3D volume. For the sake of simplicity, only a homogeneous tissue is modeled, assuming the same properties for healthy and pathologic tissues. The non-linear dependence of tissue conductivity on the electric field due to the electroporation effect is modeled. The implemented model has been validated against a state of the art finite element solver, and the server has undergone a heavy load test to ensure reliability and to report execution times.

Results

The electric field is rapidly computed for any electrode and tissue configuration, and alternative setups can be easily compared. The platform provides the same results as the state of the art finite element solver (Dice = 98.3 ± 0.4 %). During the high load test, the server remained responsive. Simulations are computed in less than 2 minutes for simple cases consisting of two electrodes and take up to 40 minutes for complex scenarios consisting of 6 electrodes.

Conclusions

With this free platform we provide expert and non-expert electroporation users a way to rapidly model the electric field distribution for arbitrary electrode configurations.

Keywords

Electroporation

web platform

electric field visualization

modeling

simulation

treatment planning

electrochemotherapy

irreversible electroporation

View full text

© 2020 Published by Elsevier B.V.



Source link