Título: Allogenic Natural Killer Cell Immunotherapy Combined with Irreversible Electroporation for Stage IV Hepatocellular Carcinoma: Survival Outcome Autores: Mohammed Alnaggar, Mao Lin, Adnan Mesmar, Shuzhen Liang, Ammar Qaid, Kecheng Xu, Jibing Chen, Lizhi Niu, Zhinan Yin Fuente: Cellular Physiology and Biochemistry, Vol 48, Iss 5, Pp 1882-1893 (2018) Información del Publicador: Cell Physiol Biochem Press GmbH & Co KG, 2018. Año de Publicación: 2018 Colección: DOAJ-Articles_enriched
DOAJ-Articles Términos de Temas: QP1-981, Median overall survival, QD415-436, fungi, Biochemistry, Adverse effects, Physiology, Allogenic natural killer cell, Hepatocellular cancer, Irreversible electroporation Descripción: Background/Aims: We evaluated the clinical effectiveness of irreversible electroporation (IRE) in combination with immunotherapy using allogenic natural killer cells (NK) for stage IV hepatocellular carcinoma (HCC). Methods: The study involved 40 patients with stage IV HCC who were divided equally into two groups: 1) simple IRE; and 2) IRE plus allogenic NK cells (IRE-NK); we mainly assessed the overall survival (OS). Results: The effect of the IRE-NK treatment was synergistic, i.e., not only did it enhance immune function, it also decreased alpha-fetoprotein expression and showed significantly good clinical effectiveness. At the median 7.6-month follow-up (range, 3.8–12.1 months), median OS was higher in the IRE-NK group (10.1 months) than in the IRE group (8.9 months, P = 0.0078). Conclusion: IRE combined with allogeneic NK cell immunotherapy significantly increases the median OS of patients with stage IV HCC. Idiomas: English ISSN: 1421-9778
1015-8987 DOI: 10.1159/000492509 Número de Acceso: edsair.doajarticles..5c12939d564b27904f7d9f3978d94b61 Base de Datos: OpenAIRE



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