New York, USA - Creative Biolabs, a remarkable servicer in the CAR production, has developed CAR-T Gene Packaging & Delivery services, which can be conducted in multiple cell lines, primary cells, stem cells, hematopoietic cells, and neuronal cells.
As is known, T cell receptor gene transfer is the key to a successful manufacture of CAR-T cells. Therefore, a complete and professional T cell transfection service with high-quality CAR Virus Packing Kits play an indispensable role in a one-stop CAR-T therapy development service.
In order to avoid the high toxicity and low efficiency brought by non-viral methods, Creative Biolabs offers clients reliable and cost-effective Virus Based Transfection and Electric Transfection Services.
Viral vectors are characterized by easy production and stable integrating ability. Based on the advanced technology platform, Creative Biolabs can optimize the process of viral based transfection to ensure replication incompetence, low genotoxicity, and low immunogenicity. Gamma-retrovirus (simple retrovirus, retroviral, MLV) transduction enables the integration of artificial genes into the host genome in a stable status, and perturb the genomic region and result in neoplastic transformation. Lentiviral vectors mediate potent transduction and stable expression into dividing and non-dividing cells both in vitro and in vivo, improve the specificity, efficacy, and safety.
Electroporation, another powerful tool for Electric Transfection, can be used with a variety of cell types, especially T cells, yielding a high frequency of both stable transformation and transient gene expression. The process of electroporation transfection has also been optimized by experts at Creative Biolabs to distribute the electrical pulse equally among the cells, maintain a stable pH and modify the pulse and field strength parameters to reduce the loss as described above.
"Our professional team with first class technologies has accumulated years of practical experience. We can guarantee our clients efficient electric transfection services. The electric process is conducted in a short time without any harmful viability", said the scientist at Creative Biolabs.
"We also developed transposons based transfection system which is different from virial transfection. Our academic clients can carry out the whole procession of CAR producing with this featured service, which is famous for its higher capacity of carrying target DNA, efficiency of gene movement and higher safety than the virial vectors. It can be a robust helper for our clients."
Apart from CAR-T Gene Packaging & Delivery services, Creative Biolabs has also established a comprehensive platform for one-stop CAR-T services. More information can be reached at www.creative-biolabs.com/car-t.
About Creative Biolabs
As a global company, Creative Biolabs has more than 200 talented and well-trained scientists located in different continents working closely with partners from the entire world to develop and produce medicines of tomorrow. Specifically, the established leading experts in TCR and CAR T&NK cell immune therapy development offer the one-stop custom services that cover the entire new drug development pipeline, and an exclusive line of ready-to-use TCR and CAR T&NK cell construction products, such as virus packaging, purification, expansion and titer determination kits. Furthermore, a unique unparalleled CAR construction and production platform has been built up for all four CAR generations.